{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:03:09Z","timestamp":1792854189662,"version":"4.5.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T00:00:00Z","timestamp":1689465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Mechanical thrombectomy (MT) has become the standard of care for patients with acute ischemic stroke secondary to large vessel occlusion (LVO) of the anterior circulation. Conversely, its benefit in patients with National Institutes of Health Stroke Scale (NIHSS) score\u2009\u2a7d\u20095 is unproven.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To demonstrate the superiority of immediate MT plus best medical treatment (BMT) compared to BMT (with secondary MT in case of deterioration) for increasing the rate of modified Rankin Scale (mRS) score\u2009\u2a7d\u20091 at 90\u2009days after minor stroke (NIHSS score\u2009\u2a7d\u20095) and anterior circulation LVO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sample size estimates:<\/jats:title>\n                    <jats:p>To detect an absolute increase of 10% (80% power) in the 90-day mRS score\u2009=\u20090\u20131 rate in the MT\u2009+\u2009BMT group, by assuming an mRS score\u2009=\u20090\u20131 rate of 60% in the BMT group and by considering two interim efficacy\/futility analyses (after study completion by 274 and 548 patients), 824 patients must be included by 36 centers in France, Spain, and the USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and design:<\/jats:title>\n                    <jats:p>MOSTE is an international, multicenter, prospectively randomized into two parallel (1:1) arms, open-label, with blinded endpoint trial. Eligibility criteria are diagnosis of acute ischemic stroke within 23\u2009h of last-seen-well, NIHSS score\u2009\u2a7d\u20095, and LVO in the anterior circulation (intracranial internal carotid artery, M1 or M1-M2 segment of the middle cerebral artery).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study outcomes:<\/jats:title>\n                    <jats:p>The primary endpoint is the rate of excellent outcome at day 90 (mRS score\u2009=\u20090\u20131). Secondary endpoints include the rates of 90-day mRS score\u2009=\u20090\u20132 and score\u2009=\u20090, NIHSS score change, secondary MT, revascularization and infarct volume growth at 24\u2009h, and quality of life and cognitive function at day 90. Safety outcomes (90-day all-cause mortality, procedural complications, symptomatic intracerebral hemorrhage, and rapid NIHSS score worsening) are recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The MOSTE trial will determine MT efficacy and safety in patients with minor stroke and LVO in the anterior circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>MOSTE Trial. NCT 03796468<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930231186039","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T09:10:30Z","timestamp":1687597830000},"page":"1255-1259","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Evaluation of acute mechanical revascularization in minor stroke (NIHSS score\u2009\u2a7d\u20095) and large vessel occlusion: The MOSTE multicenter, randomized, clinical trial protocol"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7347-1039","authenticated-orcid":false,"given":"Caroline","family":"Arquizan","sequence":"first","affiliation":[{"name":"Department of Neurology, H\u00f4pital Gui de Chauliac, Montpellier, France"},{"name":"INSERM U1266, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Lapergue","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Foch, Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-4464","authenticated-orcid":false,"given":"Benjamin","family":"Gory","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Central, Nancy, France"},{"name":"IADI, INSERM U1254, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Lille University Hospital, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Henon","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Salengro, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Albucher","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Pierre-Paul Riquet, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Sibon","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Pellegrin, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-4095","authenticated-orcid":false,"given":"Guillaume","family":"Turc","sequence":"additional","affiliation":[{"name":"INSERM U1266, Paris, France"},{"name":"Department of Neurology, H\u00f4pital Sainte-Anne, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Neurology, H\u00f4pital Central, Nancy, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Di Maria","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Foch, Suresnes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Duhamel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Lille University Hospital, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor","family":"Jovin","sequence":"additional","affiliation":[{"name":"Cooper Neurological Institute, Camden, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Costalat","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Gui de Chauliac, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the MOSTE Trial 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