{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:16:34Z","timestamp":1788066994647,"version":"build-2784847793"},"reference-count":78,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Whether thrombolysis improves outcomes in non-arteritic central retinal artery occlusion (naCRAO) is uncertain. We aimed to evaluate the rate of visual recovery after intra-venous thrombolysis (IVT) or intra-arterial thrombolysis (IAT) administration of tissue plasminogen activator (tPA) or urokinase among patients with naCRAO and explore the parameters affecting the final visual acuity (VA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We systematically searched six databases. Logarithm of the minimum angle of resolution (logMAR) and VA of \u2a7e20\/100 were used to quantify visual recovery. To explore the role of other factors on visual recovery, we defined two models for studies with aggregated data (designs 1 and 2) and 16 models for individual participant data (IPD, models 1\u201316).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary of Review:<\/jats:title>\n                    <jats:p>We included data from 771 patients out of 72 publications in nine languages. Visual improvement for \u2a7e0.3 logMAR was reported in 74.3% of patients who received IVT-tPA within 4.5\u2009h (CI: 60.9\u201386.0%; unadjusted rate: 73.2%) and 60.0% of those who received IAT-tPA within 24\u2009h (CI: 49.1\u201370.5%; unadjusted rate: 59.6%). VA of \u2a7e20\/100 was observed among 39.0% of patients after IVT-tPA within 4.5\u2009h and 21.9% of those with IAT-tPA within 24\u2009h. IPD models highlighted the association between improved visual outcomes and VA at presentation, at least 2 weeks follow-up before reporting the final VA, antiplatelet therapy, and shorter symptom onset to thrombolysis window.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early thrombolytic therapy with tPA is associated with enhanced visual recovery in naCRAO. Future studies should refine the optimum time window for thrombolysis in naCRAO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930231189352","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T02:56:10Z","timestamp":1688957770000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":29,"title":["Thrombolysis for central retinal artery occlusion: An individual participant-level meta-analysis"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-9492","authenticated-orcid":false,"given":"Shima","family":"Shahjouei","sequence":"first","affiliation":[{"name":"Department of Neurology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA"},{"name":"Department of Neurology, Neurosurgery, and Translational Medicine, Barrow Neurological Institute, St. Joseph\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Bavarsad Shahripour","sequence":"additional","affiliation":[{"name":"UCSD Comprehensive Stroke Center, Department of Neurosciences, University of California, San Diego, CA, USA"},{"name":"Department of Neurology, Stroke Center, Loma Linda University, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana M","family":"Dumitrascu","sequence":"additional","affiliation":[{"name":"Division of Cerebrovascular Diseases, Department of Neurology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ, USA"},{"name":"Department of Ophthalmology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"bibr1-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.038"},{"key":"bibr2-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.005"},{"key":"bibr3-17474930231189352","volume":"1","author":"Fraser SG","year":"2009","journal-title":"Cochrane Database of Syst Rev"},{"key":"bibr4-17474930231189352","volume":"127","author":"Flaxel CJ","year":"2020","journal-title":"Ophthalmology"},{"key":"bibr5-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e318296aeca"},{"key":"bibr6-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000366"},{"key":"bibr7-17474930231189352","volume":"50","author":"Powers WJ","year":"2019","journal-title":"Stroke"},{"key":"bibr8-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)76167-7"},{"key":"bibr9-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001027"},{"key":"bibr10-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000129"},{"key":"bibr11-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001989.pub3"},{"key":"bibr12-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007134"},{"key":"bibr13-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00076"},{"key":"bibr14-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1578"},{"key":"bibr15-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028743"},{"key":"bibr16-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-022-05797-1"},{"key":"bibr17-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10838-6"},{"key":"bibr18-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01626-4"},{"key":"bibr19-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.06.016"},{"key":"bibr20-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.3656"},{"key":"bibr21-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"bibr22-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-017767"},{"key":"bibr23-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2020.0082"},{"key":"bibr24-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3341\/jkos.2020.61.12.1442"},{"key":"bibr25-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0926-0"},{"key":"bibr26-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.08.018"},{"key":"bibr27-17474930231189352","volume":"355","author":"Sterne JA","year":"2016","journal-title":"BMJ"},{"key":"bibr28-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"bibr29-17474930231189352","unstructured":"Kreiliger G. Statistical assessment and adjustment of publication bias in the cochrane database of systematic reviews. Doctoral Dissertation, University of Zurich, Zurich, 2019."},{"key":"bibr30-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"bibr31-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31815c24e7"},{"key":"bibr32-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051430"},{"key":"bibr33-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.7.1.105"},{"key":"bibr34-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3102\/10769986018003271"},{"key":"bibr35-17474930231189352","first-page":"1167","volume":"88","author":"Annonier P","year":"1988","journal-title":"Bull Soc Ophtalmol Fr"},{"key":"bibr36-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/s003470050069"},{"key":"bibr37-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105988"},{"key":"bibr38-17474930231189352","first-page":"507","volume":"26","author":"Derieux L","year":"2003","journal-title":"J Fr Ophtalmol"},{"key":"bibr39-17474930231189352","first-page":"565","volume":"20","author":"Padolecchia R","year":"1999","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr40-17474930231189352","author":"Zhao X","year":"1996","journal-title":"Chinese Journal of Ocular Fundus Diseases"},{"key":"bibr41-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1177\/1538574416682158"},{"key":"bibr42-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2009.04.022"},{"key":"bibr43-17474930231189352","first-page":"1203","volume":"11","author":"Tsai FY","year":"1990","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr44-17474930231189352","first-page":"619","volume":"33","author":"Tagawa M","year":"2005","journal-title":"No Shinkei Geka"},{"key":"bibr45-17474930231189352","first-page":"445","volume":"32","author":"Zhizhong M","year":"1996","journal-title":"Chin J Ophthalmol"},{"key":"bibr46-17474930231189352","first-page":"245","volume":"64","author":"Mach R","year":"2008","journal-title":"\u010ces a Slov Oftai"},{"key":"bibr47-17474930231189352","first-page":"287","volume":"75","author":"Cilveti Puche A","year":"2000","journal-title":"Arch Soc Esp"},{"key":"bibr48-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90165-3"},{"key":"bibr49-17474930231189352","doi-asserted-by":"crossref","unstructured":"Schmidt D, Schumacher M. Stage-dependent efficacy of intra-arterial fibrinolysis in central retinal artery occlusion (CRAO) 1998; 20: 125\u2013141.","DOI":"10.1076\/noph.20.3.125.4155"},{"key":"bibr50-17474930231189352","first-page":"149","volume":"93","author":"Vulpius K","year":"1996","journal-title":"Der Ophthalmologe"},{"key":"bibr51-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1159\/000310400"},{"key":"bibr52-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11439-7"},{"key":"bibr53-17474930231189352","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S362019"},{"key":"bibr54-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57090963"},{"key":"bibr55-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1159\/000489696"},{"key":"bibr56-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1080\/02841850312331287829"},{"key":"bibr57-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.037135"},{"key":"bibr58-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/s003470170079"},{"key":"bibr59-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.10.2076"},{"key":"bibr60-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X444008"},{"key":"bibr61-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/BF03162723"},{"key":"bibr62-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1177\/1747493016687578"},{"key":"bibr63-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.613653"},{"key":"bibr64-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.07.025"},{"key":"bibr65-17474930231189352","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S272126"},{"key":"bibr66-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1588-3"},{"key":"bibr67-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12952"},{"key":"bibr68-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800410"},{"key":"bibr69-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215340"},{"key":"bibr70-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916870"},{"key":"bibr71-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4514"},{"key":"bibr72-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106868"},{"key":"bibr73-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.819896"},{"key":"bibr74-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.0323"},{"key":"bibr75-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.06.016"},{"key":"bibr76-17474930231189352","doi-asserted-by":"publisher","DOI":"10.3390\/life12081279"},{"key":"bibr77-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505404"},{"key":"bibr78-17474930231189352","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2014.02.007"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930231189352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17474930231189352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930231189352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:22:08Z","timestamp":1777706528000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17474930231189352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/17474930231189352"],"URL":"https:\/\/doi.org\/10.1177\/17474930231189352","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]}}}