{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:17:01Z","timestamp":1791951421001,"version":"4.3.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The transmission of amyloid \u03b2 (A\u03b2) in humans leading to iatrogenic cerebral amyloid angiopathy (iCAA) is a novel concept with analogies to prion diseases. However, the number of published cases is low, and larger international studies are missing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aimed to build a large multinational collaboration on iCAA to better understand the clinical spectrum of affected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We collected clinical data on patients with iCAA from Austria, Croatia, Italy, Slovenia, and Spain. Patients were included if they met the proposed Queen Square diagnostic criteria (QSC) for iCAA. In addition, we pooled data on disease onset, latency, and cerebrospinal fluid (CSF) biomarkers from previously published iCAA cases based on a systematic literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-seven patients (22% women) were included in this study. Of these, 19 (70%) met the criteria for probable and 8 (30%) for possible iCAA. Prior neurosurgical procedures were performed in all patients (93% brain surgery, 7% spinal surgery) at median age of 8 (interquartile range (IQR)\u2009=\u20094\u201318, range\u2009=\u20090\u201326\u2009years) years. The median symptom latency was 39\u2009years (IQR\u2009=\u200934\u201341, range\u2009=\u200928\u201349). The median age at symptom onset was 49\u2009years (IQR\u2009=\u200943\u201355, range\u2009=\u200932\u201370). Twenty-one patients (78%) presented with intracranial hemorrhage and 3 (11%) with seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our large international case series of patients with iCAA confirms a wide age boundary for the diagnosis of iCAA. Dissemination of awareness of this rare condition will help to identify more affected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930231203133","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T23:52:43Z","timestamp":1694562763000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Iatrogenic cerebral amyloid angiopathy: A multinational case series and individual patient data analysis of the literature"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-3635","authenticated-orcid":false,"given":"Slaven","family":"Pikija","sequence":"first","affiliation":[{"name":"Department of Neurology, Christian Doppler University Hospital, Salzburg, Austria"},{"name":"Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-2173","authenticated-orcid":false,"given":"Janja","family":"Pretnar-Oblak","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, Faculty of Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-160X","authenticated-orcid":false,"given":"Senta","family":"Frol","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, Faculty of Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branko","family":"Malojcic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zagreb School of Medicine, University Hospital Center, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-6576","authenticated-orcid":false,"given":"Thomas","family":"Gattringer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Graz, Graz, Austria"},{"name":"Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Rak-Frattner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Krankenhaus der Barmherzigen Br\u00fcder, Eisenstadt, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitre","family":"Staykov","sequence":"additional","affiliation":[{"name":"Department of Neurology, Krankenhaus der Barmherzigen Br\u00fcder, Eisenstadt, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Salmaggi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alessandro Manzoni Hospital, Lecco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2260-9229","authenticated-orcid":false,"given":"Riccardo","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alessandro Manzoni Hospital, Lecco, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Magdic","sequence":"additional","affiliation":[{"name":"Division of Neurology, University Medical Centre Maribor, Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Iglseder","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, University Medical Centre Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler University Hospital, Salzburg, Austria"},{"name":"Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria"},{"name":"Karl Landsteiner Institute for Neurorehabilitation and Space Neurology, Salzburg, Austria"},{"name":"Department of Public Health, Health Services Research, and Health Technology Assessment, Hall in Tirol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Pathology, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler University Hospital, Salzburg, Austria"},{"name":"Neuroscience Institute, Christian Doppler University Hospital, Centre for Cognitive Neuroscience, Paracelsus Medical University, Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo C.","family":"DiFrancesco","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Tabaee Damavandi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Fabin","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, 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