{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:55:27Z","timestamp":1781070927227,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["RG85316"],"award-info":[{"award-number":["RG85316"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is a major risk factor for ischaemic stroke (IS) and transient ischaemic attack (TIA). The timely detection of first-diagnosed or \u201cnew\u201d AF (nAF) would prompt a switch from antiplatelets to anticoagulation to reduce the risk of stroke recurrence; however, the optimal timing and duration of rhythm monitoring to detect nAF remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We searched MEDLINE, PubMed, Cochrane database, and Google Scholar to undertake a systematic review and meta-analysis of randomized controlled trials (RCT) between 2012 and 2023 investigating nAF detection after IS and TIA. Outcome measures were overall detection of nAF (control; (usual care) compared to intervention; (continuous cardiac monitoring &gt;72\u2009h)) and the time period in which nAF detection is highest (0\u201314\u2009days, 15\u201390\u2009days, 91\u2013180\u2009days, or 181\u2013365\u2009days). A random-effects model with generic inverse variance weights was used to pool the most adjusted effect measure from each trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary of review:<\/jats:title>\n                    <jats:p>A total of eight RCTs investigated rhythm monitoring after IS, totaling 5820 patients. The meta-analysis of the studies suggested that continuous cardiac monitoring was associated with a pooled odds ratio of 3.81 (95% CI 2.14 to 6.77), compared to usual care (control), for nAF detection. In the time period analysis, the odds ratio for nAF detection at 0\u201314\u2009days, 15\u201390\u2009days, 91\u2013180\u2009days, 181\u2013365\u2009days were 1.79 (1.24\u20132.58); 2.01 (0.63\u20136.37); 0.98 (0.16\u20135.90); and 2.92 (1.30\u20136.56), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is an almost fourfold increase in nAF detection with continuous cardiac monitoring, compared to usual care. The results also demonstrate two statistically significant time periods in nAF detection; at 0\u201314\u2009days and 6\u201312\u2009months following monitoring commencement. These data support the utilization of different monitoring methods to cover both time periods and a minimum of 1\u2009year of monitoring to maximize nAF detection in patients after IS and TIA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930231215277","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T07:22:30Z","timestamp":1699600950000},"page":"499-505","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Identifying the optimal time period for detection of atrial fibrillation after ischaemic stroke and TIA: An updated systematic review and meta-analysis of randomized control trials"],"prefix":"10.1177","volume":"19","author":[{"given":"Mrinal","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Stroke, Cambridge University Hospitals, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Alsinbili","sequence":"additional","affiliation":[{"name":"Department of Stroke, Cambridge University Hospitals, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cambridge University Hospitals, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Warburton","sequence":"additional","affiliation":[{"name":"Department of Stroke, Cambridge University Hospitals, Cambridge, UK"},{"name":"Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayvan","family":"Khadjooi","sequence":"additional","affiliation":[{"name":"Department of Stroke, Cambridge University Hospitals, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7020-8179","authenticated-orcid":false,"given":"Isuru","family":"Induruwa","sequence":"additional","affiliation":[{"name":"Department of Stroke, Cambridge University Hospitals, Cambridge, UK"},{"name":"Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK"},{"name":"Department of Medicine, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"bibr1-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.06.030"},{"key":"bibr2-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005960"},{"key":"bibr3-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.016414"},{"key":"bibr4-17474930231215277","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-12-200706190-00007"},{"key":"bibr5-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802686"},{"key":"bibr6-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813959"},{"key":"bibr7-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70027-X"},{"key":"bibr8-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.6470"},{"key":"bibr9-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003433"},{"key":"bibr10-17474930231215277","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"bibr11-17474930231215277","unstructured":"Higgins J, Thomas J, Chandler J, et al. 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