{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:28:28Z","timestamp":1790288908430,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Moyamoya disease (MMD) is considered a progressive disease with an ongoing risk of recurrent stroke. However, there is a lack of long-term observational data to quantify the extent of the stroke risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study aimed to provide insight into the long-term stroke risk in MMD and explore possible risk factors for stroke. Records from all patients diagnosed with MMD in 13 clinical departments from 6 different Danish hospitals between 1994 and 2017 were retrospectively reviewed until 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The cohort comprised 50 patients (33 females and 17 males). Patients were followed up for a median of 9.4\u2009years, with more than 10\u2009years of follow-up for 24 patients. Ten patients had 11 new stroke events\u20146 ischemic strokes and 5 brain hemorrhages. Events occurred at a median of 7 years and up to 25\u2009years after diagnosis. The overall Kaplan-Meier 5-year stroke risk was 10%. Patients with bypass performed had significantly fewer events than conservatively treated patients (HR 0.25, 95% confidence interval (CI) 0.07\u20130.91, p\u2009&lt;\u20090.05). All but one event occurred in females, a difference that reached statistical significance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study provides data on the extent of the risk of recurrent stroke in MMD. Bypass surgery patients had fewer stroke events than those treated conservatively. There was a trend toward a higher stroke risk in females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data access statement:<\/jats:title>\n                    <jats:p>The data supporting this study\u2019s findings are available from the corresponding author upon reasonable request.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930231216037","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:29:58Z","timestamp":1699662598000},"page":"452-459","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term stroke risk in Moyamoya disease"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2385-5418","authenticated-orcid":false,"given":"Peter","family":"Birkeland","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Copenhagen University Hospital, K\u00f8benhavn \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinosha","family":"Tharmabalan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Copenhagen University Hospital, K\u00f8benhavn \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Lauritsen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Odense University Hospital, Odense C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Truelsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Copenhagen University Hospital, K\u00f8benhavn \u00d8, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bispebjerg Hospital, K\u00f8benhavn, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"von Weitzel-Mudersbach","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Danish Stroke Center, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"bibr1-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804622"},{"key":"bibr2-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301387"},{"key":"bibr3-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.130666"},{"key":"bibr4-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000182256.32489.99"},{"key":"bibr5-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.08.002"},{"key":"bibr6-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-33-6404-2_21"},{"key":"bibr7-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12708"},{"key":"bibr8-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70240-0"},{"key":"bibr9-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221144089"},{"key":"bibr10-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14439"},{"key":"bibr11-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-73739-3_13"},{"key":"bibr12-17474930231216037","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"bibr13-17474930231216037","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.52.245"},{"key":"bibr14-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.613273"},{"key":"bibr15-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.513408"},{"key":"bibr16-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000221787.70503.ca"},{"key":"bibr17-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007819"},{"key":"bibr18-17474930231216037","doi-asserted-by":"publisher","DOI":"10.2176\/jns-nmc.2021-0382"},{"key":"bibr19-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004386"},{"key":"bibr20-17474930231216037","first-page":"1","volume":"2020","author":"Kuroda S","journal-title":"J Neurosurg"},{"key":"bibr21-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319915"},{"key":"bibr22-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03481.x"},{"key":"bibr23-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017701"},{"key":"bibr24-17474930231216037","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2015.1096902"},{"key":"bibr25-17474930231216037","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12702"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930231216037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17474930231216037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930231216037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:22:29Z","timestamp":1777706549000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17474930231216037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/17474930231216037"],"URL":"https:\/\/doi.org\/10.1177\/17474930231216037","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]}}}