{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:34:31Z","timestamp":1790346871783,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","award":["PHO018177"],"award-info":[{"award-number":["PHO018177"]}],"id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024838","name":"Samsung Medical Center","doi-asserted-by":"crossref","award":["OTX000036"],"award-info":[{"award-number":["OTX000036"]}],"id":[{"id":"10.13039\/501100024838","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed compare efficacy of edoxaban and enoxaparin upon biomarkers of hypercoagulability in patients with cancer-related embolic stroke of undetermined source (ESUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this open-label, randomized, pilot trial, patients with cancer-related ESUS within 30\u2009days of diagnosis were randomly assigned (1:1) to receive edoxaban (60\u2009mg once daily) or enoxaparin (1\u2009mg\/kg twice daily) for 90\u2009days. The primary endpoint was interval change of serum D-dimer level between days 0 and 7. The secondary endpoints were microembolic signals detected by transcranial Doppler at 7 and 90\u2009days, the modified Rankin scale score, and stroke recurrence during 90\u2009days. Safety outcomes included major bleeding and all-cause death at 90\u2009days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 303 patients with ischemic stroke and cancer, 40 fully met enrollment criteria and were randomized. Baseline D-dimer levels were numerically higher in the edoxaban group (22.9\u2009\u00b1\u200915.9\u2009\u03bcg\/mL vs 16.9\u2009\u00b1\u200916.9\u2009\u03bcg\/mL). D-dimer level change (%) between days 0 and 7 was similar in the two groups (53.2\u2009\u00b1\u200925.7 vs 52.2\u2009\u00b1\u200952.0; P\u2009=\u20090.11). Microembolic signals were detected in 41.1% and 43.8% at baseline, 41.2% and 42.9% at day 7, and 25.0% and 28.6% at day 90 in the edoxaban and enoxaparin groups, respectively. Non-significantly higher major bleeding (35.0% vs 10.0%, P\u2009=\u20090.06) and 90-day mortality (40.0% vs 25.0%, P\u2009=\u20090.31) were noted in the edoxaban group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Edoxaban and enoxaparin were comparable with respect to the biomarkers of hypercoagulability and cerebral thromboembolism. Larger trials are warranted to compare effects of edoxaban and enoxaparin upon recurrent stroke and major bleeding in patients with cancer-related ESUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>clinicaltrials.gov Identifier: NCT03570281 ( https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03570281 )<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930241239266","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T23:00:55Z","timestamp":1709334055000},"page":"645-653","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Edoxaban for the treatment of hypercoagulability and cerebral thromboembolism associated with cancer: A randomized clinical trial of biomarker targets"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-8899","authenticated-orcid":false,"given":"Jong-Won","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaechun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-8434","authenticated-orcid":false,"given":"Woo-Keun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Ju","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-2251","authenticated-orcid":false,"given":"Jeffrey L","family":"Saver","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Young","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"bibr1-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129912.56486.2B"},{"key":"bibr2-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24325"},{"key":"bibr3-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.05.031"},{"key":"bibr4-17474930241239266","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2016.00570"},{"key":"bibr5-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019876538"},{"key":"bibr6-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13596"},{"key":"bibr7-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"bibr8-17474930241239266","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0084"},{"key":"bibr9-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1711948"},{"key":"bibr10-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915103"},{"key":"bibr11-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-022-00399-7"},{"key":"bibr12-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12002"},{"key":"bibr13-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.032002"},{"key":"bibr14-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"bibr15-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26129"},{"key":"bibr16-17474930241239266","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00528"},{"key":"bibr17-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22050"},{"key":"bibr18-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-571232"},{"key":"bibr19-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014458"},{"key":"bibr20-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4211"},{"key":"bibr21-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"bibr22-17474930241239266","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00434"},{"key":"bibr23-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.571356"},{"key":"bibr24-17474930241239266","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-014-1145-7"},{"key":"bibr25-17474930241239266","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.02278"}],"container-title":["International 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