{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:38:25Z","timestamp":1792201105053,"version":"4.4.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Paroxysmal atrial fibrillation (PAF) is strongly associated with ischemic stroke. Continuous cardiac implantable electronic devices (CIEDs) can assess PAF episodes over prolonged periods. Studies that attempted to find a temporal association between PAF and ischemic stroke were inconclusive. Thus, we performed a systematic review and meta-analysis to assess this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to assess the temporal association between AF episodes and stroke within 30\u2009days of the arrhythmic episode. The secondary outcome is a temporal association within a 90-day period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary of review:<\/jats:title>\n                    <jats:p>A total of 2804 studies that discussed the temporal relationship between PAF and ischemic stroke were screened, and 7 studies were included in the meta-analysis. Among the 4041 patients included in these studies, there were 138 patients with device detected PAF episodes and stroke. Four studies used a 30-day window for temporality and the pooled odds ratio (OR) showed a significant association (OR 4.11 (95% CI 1.03\u201316.40)). The three studies reporting on AF and stroke within a 90-day window did not find a significant temporal relationship (OR 0.43 (95% CI 0.13\u20131.41)). Finally, the pooled result of those seven studies did not show a significant association (OR 1.51 (95% CI 0.44\u20135.17)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This meta-analysis supports a temporal relationship between PAF and ischemic stroke within a 30-day window. Establishing this relationship is important for individualized risk prediction and targeted anticoagulation treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data access statement:<\/jats:title>\n                    <jats:p>The data will be made available upon reasonable request.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930241253482","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T08:14:14Z","timestamp":1714205654000},"page":"1083-1092","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Temporal association between atrial fibrillation and ischemic stroke: Systematic review and meta-analysis"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-3620","authenticated-orcid":false,"given":"Jessica","family":"D\u2019lima","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia"},{"name":"Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Thijs","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia"},{"name":"Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australi"},{"name":"Department of Neurology, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han S","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia"},{"name":"Department of Cardiology, Austin Health, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalys Sampaio","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Marie","family":"Beaudoin","sequence":"additional","affiliation":[{"name":"University of Sherbrooke, Sherbrooke, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"bibr1-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.3702"},{"key":"bibr2-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007825"},{"key":"bibr3-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108602"},{"key":"bibr4-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.04.022"},{"key":"bibr5-17474930241253482","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000181"},{"key":"bibr6-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1055\/a-1346-2899"},{"key":"bibr7-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05104-6"},{"key":"bibr8-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-014-9879-x"},{"key":"bibr9-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.06.022"},{"key":"bibr10-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104934"},{"key":"bibr11-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv115"},{"key":"bibr12-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01698-6"},{"key":"bibr13-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.003057"},{"key":"bibr14-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031822"},{"key":"bibr15-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1159\/000526088"},{"key":"bibr16-17474930241253482","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14061"},{"key":"bibr17-17474930241253482","volume":"29","author":"Biby 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