{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:00:09Z","timestamp":1792166409147,"version":"4.4.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Stroke is a common complication of infective endocarditis (IE). Our aim was to describe the prevalence and prognostic impact of stroke in a national cohort of IE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Consecutive inclusion at 46 Spanish hospitals between 2008 and 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Out of 5667 IE cases, 1125 had acute stroke (19.8%): 818 ischemic strokes (811 cardioembolic strokes (193 with hemorrhagic transformation), 4 transient ischemic attacks, 3 lacunar infarctions), 127 intracranial hemorrhages, and 27 other neurological complications (cerebral abscesses, encephalitis, and meningitis). Compared to patients without stroke, those with stroke had a similar mean age (69\u2009years) but were more frequently female (68.2% vs 63.7%, p\u2009=\u20090.04) and had a higher incidence of intracardiac complications (35% vs 30%, p\u2009=\u20090.01), surgical indication (69.9% vs 65.9%, p\u2009=\u20090.001), in-hospital mortality (40.9% vs 22.0%, p\u2009&lt;\u20090.001), and 1-year mortality (46.2% vs 27.9%, p\u2009&lt;\u20090.001). The following variables were independently associated with stroke: mitral location (odds ratio (OR)\u2009=\u20091.5, 95% confidence interval (CI)\u2009=\u20091.34\u20131.8, p\u2009&lt;\u20090.001), vascular phenomenon (OR\u2009=\u20092.9, 95% CI\u2009=\u20092.4\u20133.6, p\u2009=\u20090.0001), acute renal failure (OR\u2009=\u20091.2, 95% CI\u2009=\u20091.0\u20131.4, p\u2009=\u20090.021), septic shock (OR\u2009=\u20091.3, 95% CI\u2009=\u20091.1\u20131.6, p\u2009=\u20090.007), sepsis (OR\u2009=\u20091.3, 95% CI\u2009=\u20091.1\u20131.6, p\u2009=\u20090.005), surgery indicated but not performed (OR\u2009=\u20091.4, 95% CI\u2009=\u20091.2\u20131.7, p\u2009&lt;\u20090.001), community-acquired IE (OR\u2009=\u20091.2, 95% CI\u2009=\u20091\u20131.4, p\u2009=\u20090.017), and peripheral embolization (OR\u2009=\u20091.6, 95% CI\u2009=\u20091.4\u20131.9, p\u2009&lt;\u20090.001). Stroke was an independent predictor of in-hospital (OR\u2009=\u20092.1, 95% CI\u2009=\u20091.78\u20132.51, p\u2009&lt;\u20090.001) and 1-year mortality (hazard ratio\u2009=\u20091.9, 95% CI\u2009=\u20091.6\u20132.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>One-fifth of patients with IE have concomitant stroke. Stroke is associated with mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930241255560","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T06:00:46Z","timestamp":1714975246000},"page":"989-998","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence and prognostic impact of stroke in a national cohort of infective endocarditis"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-0886","authenticated-orcid":false,"given":"Sara","family":"\u00c1lvarez-Zaballos","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"V\u00e1zquez-Alen","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital General Universitario 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Carmen","family":"Fari\u00f1as","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Universitario Marqu\u00e9s de Valdecilla IDIVAL, Santander, Spain"},{"name":"CIBER de Enfermedades Infecciosas-CIBERINFEC (CB21\/13\/00068), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"University of Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Rodr\u00edguez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Intensive Medicine Department, Hospital Universitario Central de Asturias, Oviedo, Spain"},{"name":"University of Oviedo, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Goenaga","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Universitario Donosti, ISS Biodonostia, San Sebasti\u00e1n, 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