{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:09:08Z","timestamp":1777943348060,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>According to the literature, about one third of patients with brain ischemic symptoms lasting &lt;24\u2009h, which are classified as Transient ischemic attacks (TIAs) according to the traditional \u201ctime-based\u201d definition, show the presence of acute ischemic lesions at neuroimaging. Recent evidence has shown that the presence of acute ischemic lesions at neuroimaging may impact on the outcome of patients with transient ischemic symptoms treated with dual antiplatelet treatment (DAPT). This uncertainty is even more compelling in recent years as short-term DAPT has become the standard treatment for any non-cardioembolic TIA or minor ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      This is a pre-specified subgroup analysis from a prospective multicenter real-world study (READAPT). The analysis included patients with time-based TIA\u2014that is, those with ischemic symptoms lasting &lt;24\u2009h\u2014who started DAPT. In the whole population, we assessed the presence of acute brain ischemic lesions at neuroimaging and their association with the ABCD\n                      <jats:sup>2<\/jats:sup>\n                      score. To assess the impact of acute brain ischemic lesions on 90-day prognosis, we performed a propensity score matching of patients with and without those lesions. We adopted a primary effectiveness outcome which was a composite of new stroke\/TIA events and death due to vascular causes at 90\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We included 517 patients\u2014324 (62.7%) male\u2014with a median (interquartile range\u2014IQR) age of 74 (IQR\u2009=\u200965\u201381) years; 144 patients (27.9%) had acute brain ischemic lesions at neuroimaging. The proportion of patients with brain ischemic lesions did not vary according to the ABCD\n                      <jats:sup>2<\/jats:sup>\n                      score. At follow-up, 4 patients with brain ischemic lesions (2.8%) and 21 patients without lesions (5.6%) reported the primary effectiveness outcome, which was similar between the groups before (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.178) and after matching (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.518).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our population, patients with transient ischemic symptoms and acute ischemic lesions at brain magnetic resonance imaging (MRI) had a risk of recurrent ischemic events similar to those without lesions. The risk of recurrent ischemic events was low in both groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930241302691","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T02:25:17Z","timestamp":1731983117000},"page":"426-437","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Transient brain ischemic symptoms and the presence of ischemic lesions at neuroimaging: Results from the READAPT study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-4031","authenticated-orcid":false,"given":"Raffaele","family":"Ornello","sequence":"first","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-7155","authenticated-orcid":false,"given":"Matteo","family":"Foschi","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-6427","authenticated-orcid":false,"given":"Federico","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Maurizio Bufalini Hospital, AUSL Romagna, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Saia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cenciarelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Citt\u00e0 di Castello Hospital, Citt\u00e0 di Castello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Bedetti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Citt\u00e0 di Castello Hospital, Citt\u00e0 di Castello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Padiglioni","sequence":"additional","affiliation":[{"name":"Department of Neurology, Citt\u00e0 di Castello Hospital, Citt\u00e0 di Castello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Censori","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Cremona Hospital, Cremona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Puglisi","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Cremona Hospital, Cremona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Vinciguerra","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Cremona Hospital, Cremona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-2187","authenticated-orcid":false,"given":"Maria","family":"Guarino","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Department of Neurology, Policlinico S. 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Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Terruso","sequence":"additional","affiliation":[{"name":"Department of Neurology, AOOR Villa Sofia-Cervello, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Mannino","sequence":"additional","affiliation":[{"name":"Department of Neurology, AOOR Villa Sofia-Cervello, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Scoditti","sequence":"additional","affiliation":[{"name":"Department of Emergency\u2014Neurology\u2014Stroke Care, University Hospital of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pezzini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1604-6594","authenticated-orcid":false,"given":"Giovanni","family":"Frisullo","sequence":"additional","affiliation":[{"name":"Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Muscia","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST-Ovest Milanese, Legnano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-8795","authenticated-orcid":false,"given":"Maurizio","family":"Paciaroni","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Internal and Cardiovascular Medicine, University Hospital Santa Maria della Misericordia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-9160","authenticated-orcid":false,"given":"Maria Giulia","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Internal and Cardiovascular Medicine, University Hospital Santa Maria della Misericordia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-4507","authenticated-orcid":false,"given":"Andrea","family":"Zini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Department of Neurology and Stroke Center, Maggiore Hospital, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggiero","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Unit, \u201cM. 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Eugenio Hospital, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Marcon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cazzavillan Hospital Arzignano, Vicenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Tassi","sequence":"additional","affiliation":[{"name":"Stroke Unit, Urgency and Emergency Department, Azienda Ospedaliera Universitaria Senese, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Sanzaro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Umberto I Hospital, Siracusa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Paci","sequence":"additional","affiliation":[{"name":"UOC Neurologia, Ospedale \u201cMadonna del Soccorso,\u201d San Benedetto del Tronto, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Viticchi","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Medicine Department, Marche Polytechnic University, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Orsucci","sequence":"additional","affiliation":[{"name":"Unit of Neurology-San Luca Hospital, Lucca and Castelnuovo Garfagnana, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Falcou","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Interventional Neuroradiology and Neurology, University of Rome La Sapienza, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Diamanti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori Monza, Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Tarletti","sequence":"additional","affiliation":[{"name":"SCDU Neurologia\u2014Stroke Unit, Azienda Ospedaliero-Universitaria \u201cMaggiore della Carit\u00e0,\u201d Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Nencini","sequence":"additional","affiliation":[{"name":"Stroke Unit, Careggi University Hospital, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Rota","sequence":"additional","affiliation":[{"name":"Department of Neurology, San Giacomo Hospital, Novi Ligure, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica Nicoletta","family":"Sepe","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neurology, SS. 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