{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:09:17Z","timestamp":1777943357080,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Short-term dual antiplatelet treatment (DAPT) is superior to single antiplatelet treatment (SAPT) for secondary prevention in non-cardioembolic minor ischemic stroke and high-risk transient ischemic attack (TIA). As the real-world use of DAPT is broader than in trials, it is important to clarify its benefit\/risk profile in a diverse population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Post hoc analysis of prospectively collected data from the READAPT cohort and three prospective stroke registries including patients with mild-to-moderate (National Institute of Health Stroke Scale (NIHSS) score 0\u201310) ischemic stroke receiving early DAPT or SAPT. The primary effectiveness outcome was 90-day return to pre-stroke neurological functioning using modified Rankin Scale (mRS) score. Secondary effectiveness outcomes were 90-day mRS shift, new ischemic stroke\/TIA, vascular and all-cause death, 24\u2009h early neurological improvement or deterioration. The safety outcome was 90-day intracranial hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We matched 1008 patients treated with DAPT and 1008 treated with SAPT. Compared to SAPT, patients treated with DAPT showed higher likelihood of 90-day primary effectiveness outcome (87.5% vs. 84.4%, risk difference 3.1% (95% confidence interval (CI): 0.1%\u20136.1%); p\u2009=\u20090.047, risk ratio 1.03 (95% CI: 1.01\u20131.07); p\u2009=\u20090.043) and higher rate of 24-h early neurological improvement (25.3% vs. 15.4%, risk difference 9.9% (95% CI: 6.4%\u201313.4%); p\u2009&lt;\u20090.001, risk ratio 1.65 (95% CI: 1.37\u20131.97); p\u2009&lt;\u20090.001). No differences were observed for other study outcomes. Subgroup analysis confirmed benefit of DAPT over SAPT for primary effectiveness outcome in patients with moderate stroke, those treated with intravenous thrombolysis, and those who received antiplatelet loading dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our findings suggest that DAPT use might be safe and more effective than SAPT even in the real world and in patients who do not strictly fulfill the criteria of landmark large clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930241302991","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T06:27:22Z","timestamp":1731911242000},"page":"438-449","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Real-world comparison of dual versus single antiplatelet treatment in patients with non-cardioembolic mild-to-moderate ischemic stroke: A propensity matched analysis"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-7155","authenticated-orcid":false,"given":"Matteo","family":"Foschi","sequence":"first","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-4031","authenticated-orcid":false,"given":"Raffaele","family":"Ornello","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio","family":"D\u2019Anna","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, London, UK"},{"name":"Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"De Matteis","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L\u2019Aquila, L\u2019Aquila, Italy"},{"name":"Department of Brain Sciences, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-6427","authenticated-orcid":false,"given":"Federico","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Barone","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilina","family":"Viola","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-9160","authenticated-orcid":false,"given":"Maria Giulia","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Department of Internal and Cardiovascular Medicine, Santa Maria della Misericordia Hospital, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diletta","family":"Rosin","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Udine University Hospital, Udine, Italy"},{"name":"Dipartimento di Area Medica, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Maurizio Bufalini Hospital, AUSL Romagna, Cesena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Tassinari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cenciarelli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Citt\u00e0 di Castello Hospital, Citt\u00e0 di Castello, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Censori","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Cremona Hospital, Cremona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Zedde","sequence":"additional","affiliation":[{"name":"Neurology Unit, Stroke Unit, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, 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Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Terruso","sequence":"additional","affiliation":[{"name":"Department of Neurology, AOOR Villa Sofia-Cervello, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pezzini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Parma, Parma, Italy"},{"name":"Stroke Care Program, Department of Emergency, Parma University Hospital, Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1604-6594","authenticated-orcid":false,"given":"Giovanni","family":"Frisullo","sequence":"additional","affiliation":[{"name":"Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Muscia","sequence":"additional","affiliation":[{"name":"Department of Neurology, ASST Ovest Milanese, Legnano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-4507","authenticated-orcid":false,"given":"Andrea","family":"Zini","sequence":"additional","affiliation":[{"name":"IRCCS Istituto delle Scienze Neurologiche di Bologna, Maggiore Hospital, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggiero","family":"Leone","sequence":"additional","affiliation":[{"name":"Stroke Unit, \u201cM. 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