{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:18:08Z","timestamp":1784071088241,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center","award":["RS-2024-00398053"],"award-info":[{"award-number":["RS-2024-00398053"]}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-00265165"],"award-info":[{"award-number":["RS-2023-00265165"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Intensive blood pressure (BP) management within 24\u2009h after successful reperfusion following endovascular thrombectomy (EVT) is associated with worse functional outcomes than conventional BP management in Asian randomized controlled trials. Given the high prevalence of intracranial atherosclerotic stenosis (ICAS) in Asia, ICAS may influence these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We aimed to assess whether ICAS affects the outcomes of intensive BP management after successful EVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy\u2013Optimal Blood Pressure Control trial, which enrolled participants from June 2020 to November 2022. Patients with anterior circulation large vessel occlusion (LVO) were stratified into ICAS-related and embolic LVO groups. Clinical outcomes for intensive (target systolic BP\u2009&lt;\u2009140\u2009mm\u2009Hg) and conventional BP management (target systolic BP\u2009=\u2009140\u2013180\u2009mm\u2009Hg) were analyzed in each group. The primary outcome was a favorable outcome, defined as a modified Rankin Scale score of 0 to 2 at 3\u2009months. Safety outcomes included symptomatic intracerebral hemorrhage within 36\u2009h and stroke-related death within 3\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among 192 patients, 59 were in the ICAS-related LVO group, and 133 were in the embolic LVO group. In the ICAS-related LVO group, the rate of achieving a favorable outcome at 3\u2009months was 37.5% with intensive BP management and 55.6% with conventional management (adjusted odds ratio (OR)\u2009=\u20090.49 (95% confidence interval (CI)\u2009=\u20090.14 to 1.75); P\u2009=\u20090.27). In the embolic LVO group, these rates were 29.9% and 42.4%, respectively (adjusted OR\u2009=\u20090.64 (95% CI\u2009=\u20090.28 to 1.45); P\u2009=\u20090.29). No significant interaction was found ( P for interaction\u2009=\u20090.68). In addition, the ICAS-related LVO group receiving intensive BP management had lower rates of successful reperfusion at 24\u2009h compared to conventional management (67.7% vs. 91.7%; P\u2009=\u20090.03), while no significant difference was found in the embolic LVO group. A significant interaction effect on successful reperfusion at 24\u2009h was observed between ICAS-related and embolic LVO groups ( P for interaction\u2009=\u20090.04). No significant differences in safety outcomes were observed between intensive BP management and conventional management within both ICAS-related LVO and embolic LVO groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>ICAS did not significantly affect outcomes of intensive BP management within 24\u2009h after successful EVT. After successful reperfusion by EVT, intensive BP management should be avoided regardless of ICAS presence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data access statement:<\/jats:title>\n                    <jats:p>The data that support the findings of this study are available from the corresponding author upon reasonable request.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930241305315","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T01:45:37Z","timestamp":1732499137000},"page":"328-337","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Intensive blood pressure lowering in acute stroke with intracranial stenosis post-thrombectomy: A secondary analysis of the OPTIMAL-BP trial"],"prefix":"10.1177","volume":"20","author":[{"given":"Kwang Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeseob","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-8522","authenticated-orcid":false,"given":"Jae Wook","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-2616","authenticated-orcid":false,"given":"Young Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoonNyung","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-580X","authenticated-orcid":false,"given":"Il Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Hwan","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-0953","authenticated-orcid":false,"given":"Minyoul","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang-Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Anam Hospital, College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-491X","authenticated-orcid":false,"given":"Seong Hwan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Chosun University, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-2939","authenticated-orcid":false,"given":"Hyungjong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Research Institute, School of Medicine, Keimyung University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Research Institute, School of Medicine, Keimyung University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brain Research Institute, School of Medicine, Keimyung University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ewha Womans 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National Health Insurance Service Ilsan Hospital, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-9258","authenticated-orcid":false,"given":"Jun Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwa","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University Hospital, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukyoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Busan Paik Hospital, College of medicine, Inje University, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangbuk 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Collaboration Unit, Department of Research Affairs, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun U","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Young","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-3321","authenticated-orcid":false,"given":"Ji Hoe","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-3995","authenticated-orcid":false,"given":"Hyo Suk","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"bibr1-17474930241305315","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2023.04119"},{"key":"bibr2-17474930241305315","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.0179"},{"key":"bibr3-17474930241305315","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.14590"},{"key":"bibr4-17474930241305315","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01882-7"},{"key":"bibr5-17474930241305315","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.14330"},{"key":"bibr6-17474930241305315","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30483-X"},{"key":"bibr7-17474930241305315","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2016.00283"},{"key":"bibr8-17474930241305315","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024889"},{"key":"bibr9-17474930241305315","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00269"},{"key":"bibr10-17474930241305315","first-page":"17","author":"Nam 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