{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:09:48Z","timestamp":1791266988379,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Capitals Funds for Health Improvement and Research","award":["2022-2-2045"],"award-info":[{"award-number":["2022-2-2045"]}]},{"name":"Beijing Outstanding Young Scientist Program","award":["No. BJJWZYJH01201910025030"],"award-info":[{"award-number":["No. BJJWZYJH01201910025030"]}]},{"name":"Outstanding Young Talents Project of Capital Medical University","award":["A2105"],"award-info":[{"award-number":["A2105"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81825007"],"award-info":[{"award-number":["No. 81825007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key R and D Program of China","award":["2022YFF1501500, 2022YFF1501501, 2022YFF1501502, 20"],"award-info":[{"award-number":["2022YFF1501500, 2022YFF1501501, 2022YFF1501502, 20"]}]},{"name":"Youth Beijing Scholar Program","award":["No.010"],"award-info":[{"award-number":["No.010"]}]},{"name":"Beijing High-level Public Health Technical Personnel Construction Project","award":["Discipline leader -03-12"],"award-info":[{"award-number":["Discipline leader -03-12"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with different hypertension status could potentially respond differently to the treatment of clopidogrel-aspirin owing to thrombosis, antiplatelet resistance, and platelet reactivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The aim of the study is to examine the efficacy and safety of clopidogrel-aspirin in patients with mild ischemic stroke or high-risk transient ischemic attack (TIA) according to different hypertension status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In the Intensive Statin and Antiplatelet Therapy for Acute High-Risk Intracranial or Extracranial Atherosclerosis (INSPIRES) trial, patients were randomized to either clopidogrel-aspirin or aspirin group. The primary outcome was any new ischemic or hemorrhagic stroke within 90\u2009days. Hypertension status was classified into two categories based on medical history: patients with or without hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 6100 patients with complete data of hypertension status, 3915 (64.2%) were men. Clopidogrel-aspirin compared with aspirin was associated with reduced incidence of new stroke in patients without hypertension (hazard ratio (HR): 0.62, 95% confidence interval (CI): 0.44\u22120.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004), but not in patients with hypertension (HR: 0.87, 95% CI: 0.71\u22121.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.085 for interaction).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this study, patients without hypertension may have more benefit from receiving treatment with clopidogrel-aspirin than those with hypertension. This finding can be used as an enrichment strategy in the future secondary stroke prevention randomized clinical trials of dual antiplatelet therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>\n                      The INSPIRES trial was registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      (unique identifier: NCT03635749).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930251338618","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:02:30Z","timestamp":1748242950000},"page":"1021-1030","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of history of hypertension on efficacy of clopidogrel-aspirin in ischemic stroke"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-1082","authenticated-orcid":false,"given":"Dandan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"},{"name":"Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Claiborne","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Amarenco","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center, Assistance Publique-H\u00f4pitaux de Paris (APHP), Bichat Hospital, INSERM LVTS-U1148, University of Paris, Paris, France"},{"name":"Population Health Research Institute, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2734-5132","authenticated-orcid":false,"given":"Philip M","family":"Bath","sequence":"additional","affiliation":[{"name":"Stroke Trials Unit, Mental Health &amp; Clinical Neuroscience, University of Nottingham, Nottingham, 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