{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:34:01Z","timestamp":1784925241383,"version":"3.55.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2008-0113"],"award-info":[{"award-number":["6-2008-0113"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS-2023-00265165"],"award-info":[{"award-number":["RS-2023-00265165"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Several randomized clinical trials have indicated that intensive blood pressure (BP) lowering is associated with worse outcomes, leaving the optimal BP targets following endovascular thrombectomy (EVT) uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between specific systolic BP (SBP) thresholds, time spent outside these thresholds, and clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This post hoc analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy\u2013Optimal Blood Pressure Control (OPTIMAL-BP) trial, included patients with successful EVT randomized to intensive (&lt;140\u2009mmHg) or conventional (140\u2013180\u2009mmHg) BP management. We analyzed SBP parameters, including mean, maximum, and minimum SBP during study period, as well as excursions beyond predefined SBP thresholds (&lt;90, &lt;100, &lt;110, &gt;170, &gt;180, and &gt;190\u2009mmHg), and the cumulative and continuous durations of these excursions. Associations with 3\u2009month modified Rankin Scale (mRS) and symptomatic intracerebral hemorrhage (sICH) were assessed using multivariable logistic and ordinal regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 302 patients (median 75\u2009years; 180 [59.6%] men) were analyzed with 11,461 BP measurements recorded during the first 24 hours after EVT. Prolonged hypoperfusion (SBP below 100\u2009mmHg for continuous duration) was associated with worse mRS score (adjusted OR [aOR] 1.21 per hour, 95% CI [1.02\u20131.45]; P\u2009=\u20090.030) and increased sICH risk (aOR 1.49 per hour, 95% CI [1.15\u20131.97]; P\u2009=\u20090.004). SBP surges above 190\u2009mmHg were linked to mRS worsening (aOR 2.60, 95% CI [1.05\u20136.53]; P\u2009=\u20090.039), but upper threshold-related parameters were not significantly associated with sICH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Prolonged hypoperfusion below 100\u2009mmHg and extreme surges above 190\u2009mmHg, rather than specific SBP parameters, were associated with poor functional outcomes. These findings highlight the need for a threshold-based BP management approach post-EVT to minimize prolonged hypotension and excessive surges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930251366063","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T12:30:51Z","timestamp":1754051451000},"page":"200-211","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Blood pressure threshold and outcomes after successful endovascular thrombectomy"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-8522","authenticated-orcid":false,"given":"Jae Wook","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoonNyung","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-2616","authenticated-orcid":false,"given":"Young Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-087X","authenticated-orcid":false,"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haram","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-491X","authenticated-orcid":false,"given":"Seong Hwan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chosun University School of Medicine, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-2939","authenticated-orcid":false,"given":"Hyungjong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8884-4114","authenticated-orcid":false,"given":"Jaeseob","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonkyung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"National Health Insurance Service Ilsan Hospital, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3154-8864","authenticated-orcid":false,"given":"Kwon-Duk","family":"Seo","sequence":"additional","affiliation":[{"name":"National Health Insurance Service Ilsan Hospital, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-9258","authenticated-orcid":false,"given":"Jun Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwa","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukyoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Pusan National University School of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinkwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonsang","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-0953","authenticated-orcid":false,"given":"Minyoul","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo Han","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-7481","authenticated-orcid":false,"given":"Yang-Ha","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Guro Hospital and College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Guk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-580X","authenticated-orcid":false,"given":"Il Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Kyo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Research Affairs, Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun U","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Young","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-3321","authenticated-orcid":false,"given":"Ji Hoe","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-3995","authenticated-orcid":false,"given":"Hyo Suk","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"e_1_3_2_2_2","article-title":"Endovascular thrombectomy in patients with preexisting disability: a review","volume":"4","author":"Wechsler PM","year":"2024","unstructured":"Wechsler PM, Leslie-Mazwi T, Mistry EA. Endovascular thrombectomy in patients with preexisting disability: a review. Stroke Vasc Interv Neurol 2024; 4: e001326.","journal-title":"Stroke Vasc Interv Neurol"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930231208817"},{"key":"e_1_3_2_4_2","article-title":"Does the ischemic core really matter? An updated systematic review and meta-analysis of large core trials after TESLA, TENSION, and LASTE","volume":"4","author":"AlMajali M","year":"2024","unstructured":"AlMajali M, Dibas M, Ghannam M, et al. Does the ischemic core really matter? An updated systematic review and meta-analysis of large core trials after TESLA, TENSION, and LASTE. Stroke Vasc Interv Neurol 2024; 4: e001243.","journal-title":"Stroke Vasc Interv Neurol"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","DOI":"10.1161\/STR.0000000000000211","article-title":"Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"50","author":"Powers WJ","year":"2019","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 2019; 50: e344\u2013e418.","journal-title":"Stroke"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2018-014568"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30483-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01882-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.14330"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.14590"},{"key":"e_1_3_2_12_2","article-title":"Blood pressure management following endovascular stroke treatment: a feasibility trial and meta-analysis of outcomes","volume":"4","author":"Katsanos AH","year":"2024","unstructured":"Katsanos AH, Catanese L, Sahlas DJ, et al. Blood pressure management following endovascular stroke treatment: a feasibility trial and meta-analysis of outcomes. Stroke Vasc Interv Neurol 2024; 4: e001287.","journal-title":"Stroke Vasc Interv Neurol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211041213"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.6878"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.038088"},{"key":"e_1_3_2_18_2","first-page":"1370","article-title":"Predicting symptomatic intracranial haemorrhage after mechanical thrombectomy: the TAG score","volume":"90","author":"Montalvo M","year":"2019","unstructured":"Montalvo M, Mistry E, Chang AD, et al. Predicting symptomatic intracranial haemorrhage after mechanical thrombectomy: the TAG score. J Neurol Neurosurg Psychiatry 2019; 90: 1370\u20131374.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2019-015561"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026596"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025426"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104596"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214609"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00806-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2314741"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001913"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25434"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.489351"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.488536"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930251366063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17474930251366063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930251366063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:24:11Z","timestamp":1777706651000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17474930251366063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,30]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/17474930251366063"],"URL":"https:\/\/doi.org\/10.1177\/17474930251366063","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,30]]}}}