{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:09:40Z","timestamp":1777943380541,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100015501","name":"Qu\u1ef9 \u0110\u1ed5i m\u1edbi s\u00e1ng t\u1ea1o Vingroup","doi-asserted-by":"publisher","award":["VINIF.2023.TS.139"],"award-info":[{"award-number":["VINIF.2023.TS.139"]}],"id":[{"id":"10.13039\/501100015501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Although the efficacy and safety of endovascular treatment (EVT) for large-core ischemic stroke have been proven, most trials used perfusion imaging or included early-window patients, limiting generalizability to the late window, particularly in developing countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>We aimed to evaluate the safety and functional outcomes of EVT in large-core stroke patients treated between 12 and 24\u2009h (late window) from last known well (LKW).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a prospective, multicenter observational study across four comprehensive stroke centers in Vietnam, enrolling consecutive patients who underwent EVT within 24 h of symptom onset between August 2023 and September 2024. Large core was defined by an Alberta Stroke Program Early CT Score (ASPECTS) of 3 to 5 on non-contrast computerized tomography (NCCT) or diffusion-weighted magnetic resonance imaging (DWI-MRI). Patients who underwent EVT within 12\u201324\u2009h after LKW were compared to those treated before 12\u2009h (early window). Primary and safety outcomes were independent ambulation (90-day modified Rankin scale (mRS) = 0\u20133) and symptomatic intracranial hemorrhage (sICH). Secondary outcomes were 90-day mRS 0\u20132, ordinal mRS, successful reperfusion (modified Thrombolysis in Cerebral Infarction score \u2a7e2b, early neurological deterioration (END)), and 90-day mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 1872 patients receiving EVT, 343 with large ischemic cores (median age = 64.0\u2009years, 33.8% female) were included, with 103 (30.0%) treated in the 12- to 24-h window. Compared to early-window patients, late-window patients had lower rates of intravenous thrombolysis (2.9% vs. 32.9%, p\u2009&lt;\u20090.001), higher brain MRI use (51.5% vs. 16.2%, p\u2009&lt;\u20090.001), and longer pre-treatment imaging-to-groin puncture times (106 vs. 77\u2009min, p\u2009&lt;\u20090.001). After adjusting for confounders, there were no significant differences in 90-day mRS 0\u20133 (56.3% vs. 55.0%, adjusted odds ratio (aOR) = 0.71, 95% confidence interval (CI) = 0.39\u20131.28, p\u2009=\u20090.26), ordinal mRS (aOR = 1.21, 95% CI = 0.78\u20131.90, p\u2009=\u20090.39), and sICH (aOR = 1.12, 95% CI = 0.32\u20133.50, p\u2009=\u20090.85). Other secondary outcomes were also similar.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In patients with anterior circulation large vessel occlusion stroke and low ASPECTS, EVT at 12\u201324 h versus &lt;12\u2009h from symptom onset showed no significant differences in clinical or safety outcomes. Larger trials are needed to confirm these findings, especially in developing regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930251367867","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T11:32:48Z","timestamp":1754652768000},"page":"242-253","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and safety outcomes following endovascular treatment for large ischemic core stroke with Alberta Stroke Program Early Computed Tomography Score 3\u20135 in the 12-to 24-h time window"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1091-9320","authenticated-orcid":false,"given":"Trung Quoc","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Cerebrovascular Disease, 115 People\u2019s Hospital, Ho Chi Minh City, Vietnam"},{"name":"University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1183-388X","authenticated-orcid":false,"given":"Khang Vinh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center HCMC, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0321-8863","authenticated-orcid":false,"given":"Hang Thi Minh","family":"Tran","sequence":"additional","affiliation":[{"name":"Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binh Nguyen","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease, 115 People\u2019s Hospital, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh Le Tuan","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease, 115 People\u2019s Hospital, Ho Chi Minh City, Vietnam"},{"name":"Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thien Quang","family":"Le","sequence":"additional","affiliation":[{"name":"Stroke Department, Da Nang Hospital, Da Nang, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai Quang","family":"Duong","sequence":"additional","affiliation":[{"name":"Stroke Department, Da Nang Hospital, Da Nang, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trung Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Stroke Department, Da Nang Hospital, Da Nang, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binh Thi Thanh","family":"Do","sequence":"additional","affiliation":[{"name":"Stroke Department, Da Nang 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