{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:05:18Z","timestamp":1791475518242,"version":"4.3.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Noncommunicable Chronic DiseasesNational Science and Technology Major Project","award":["ZD0505203"],"award-info":[{"award-number":["ZD0505203"]}]},{"name":"Beijing Natural Science Foundation \u2013 Daxing Joint Fund Project","award":["L246047"],"award-info":[{"award-number":["L246047"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vertebral artery origin stenosis (VAOS) is a common cause of posterior circulation ischemic events, and endovascular treatment serves as an alternative treatment. However, conventional endovascular treatment methods are related to high risk of restenosis. It is unclear whether the drug-coated balloon (DCB) can reduce restenosis risk of VAOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was a prospective, multicenter, randomized trial conducted from 6 January 2020 to 1 October 2023 in China. Symptomatic patients with severe VAOS were randomly allocated in a 1:1 ratio to undergo either DCB or bare-metal stent (BMS) and followed up for 12\u2009months. The primary safety endpoint was the incidence of transient ischemic attack, stroke, or death related to target vessel within 30\u2009days post-procedure. The primary efficacy endpoint was the rate of 12-month restenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 179 patients were enrolled with 91 in the DCB group and 88 in the BMS group. No significant difference was observed in the rates of transient ischemic attack, stroke, or death related to target vessel within 30\u2009days between the DCB and BMS groups (0 (0.0%) vs. 1 (1.1%); P\u2009=\u20090.49). The 12-month restenosis rate was significantly lower in the DCB group compared to the BMS group (10\/76 (13.2%) vs. 27\/76 (35.5%); risk ratio = 0.37; 95% confidence interval = 0.19 to 0.71; P\u2009=\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This trial demonstrated that DCB may reduce restenosis risk in symptomatic patients with severe VAOS compared to BMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      (unique identifier: NCT03910166).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930251377055","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:07:19Z","timestamp":1760058439000},"page":"362-371","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of drug-coated balloon in patients with severe vertebral artery origin stenosis: A multicenter randomized controlled trial"],"prefix":"10.1177","volume":"21","author":[{"given":"Jichang","family":"Luo","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"China International Neuroscience Institute, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Baotou Central Hospital, Inner Mongolia Autonomous Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute, Institute of Advanced Clinical Medicine, Peking University, Beijing, China"},{"name":"Key Laboratory of Epidemiology of Major Diseases, Ministry of Education, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rixuan","family":"Peng","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"China International Neuroscience Institute, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"China International Neuroscience Institute, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Kuai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanxi Cardiovascular Hospital, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General Hospital of Northern Theater Command of the People\u2019s Liberation Army, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Hospital of Jilin University, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Taizhou First People\u2019s Hospital, Taizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Intervention Center, Zhangzhou Hospital Affiliated to Fujian Medical University, Zhangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sir Run Run Shaw Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Wan","sequence":"additional","affiliation":[{"name":"Brain Center, Affiliated, Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangsen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease, Zhuhai People\u2019s Hospital, Zhuhai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Zhongshan Hospital of Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabing","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"China International Neuroscience Institute, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-6295","authenticated-orcid":false,"given":"Liqun","family":"Jiao","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"China International Neuroscience Institute, Beijing, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the DCB-VAOS Trial Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_3_2_2_2","article-title":"Vertebral artery stenosis: a narrative review","volume":"14","author":"Burle VS","year":"2022","unstructured":"Burle VS, Panjwani A, Mandalaneni K, Kollu S, Gorantla VR. Vertebral artery stenosis: a narrative review. Cureus 2022; 14: e28068.","journal-title":"Cureus"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930221107500"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.05.007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg003"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(00)70063-2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001824"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014537"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511081057"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.5.586"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.2.260"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.09.084"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0659-x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.06.026"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2019.0093"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2017.1284588"},{"key":"e_1_3_2_18_2","first-page":"3235","article-title":"ESC\/EACTS myocardial revascularization guidelines 2014","volume":"35","author":"Kolh P","year":"2014","unstructured":"Kolh P, Windecker S. ESC\/EACTS myocardial revascularization guidelines 2014. Eur Heart J 2014; 35: 3235\u20133236.","journal-title":"Eur Heart J"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.107065"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.09.040"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2020-016723"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.579238"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.6.711"},{"key":"e_1_3_2_24_2","unstructured":"Know (Beijing) Business Development Co. Ltd. IsCore image corelab http:\/\/imagecorelabcn.com\/en\/ (2020 accessed 2 September 2020)."},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.9.1751"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00017-4"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.611459"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1715"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.3.723"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.957332"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4804"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0059"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.09.009"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.692208"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.026"},{"key":"e_1_3_2_37_2","first-page":"828","article-title":"Balloon angioplasty vs medical management for intracranial artery stenosis: the BASIS randomized clinical trial","volume":"331","author":"Sun X","year":"2024","unstructured":"Sun X, Deng Y, Zhang Y, et al. Balloon angioplasty vs medical management for intracranial artery stenosis: the BASIS randomized clinical trial. JAMA 2024; 331: 828\u2013838.","journal-title":"JAMA"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004385"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta23410"},{"key":"e_1_3_2_40_2","first-page":"498","article-title":"First-in-human experience of sirolimus coated balloon for symptomatic intracranial artery stenosis","volume":"16","author":"Luo J","year":"2024","unstructured":"Luo J, Yang R, Wang T, et al. First-in-human experience of sirolimus coated balloon for symptomatic intracranial artery stenosis. J Neurointerv Surg 2024; 16: 498\u2013503.","journal-title":"J Neurointerv Surg"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930251377055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17474930251377055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930251377055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:24:18Z","timestamp":1777706658000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17474930251377055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/17474930251377055"],"URL":"https:\/\/doi.org\/10.1177\/17474930251377055","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}