{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:30:00Z","timestamp":1793244600257,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2021007F"],"award-info":[{"award-number":["A2021007F"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Previous studies suggest that blood\u2013brain barrier (BBB) disruption may play a role in the pathophysiology of vessel rupture in cerebral amyloid angiopathy (CAA). Here, in a cross-sectional cohort study, we apply contrast-enhanced 3 Tesla magnetic resonance imaging (MRI) to test the hypothesis that the BBB is damaged in patients with CAA and to determine whether BBB leakage is associated with hemorrhagic brain injury in CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Parenchymal BBB leakage rate (K\n                      <jats:sub>i<\/jats:sub>\n                      ) was assessed in the cortex and white matter with dynamic contrast-enhanced (DCE)-MRI and quantified with pharmacokinetic modeling. Leptomeningeal BBB leakage was assessed visually on post-contrast heavily T2-weighted fluid attenuation inversion recovery (FLAIR) images. Cortical cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) were assessed on susceptibility-weighted images. Analyses included descriptive statistics, group comparisons using the Mann\u2013Whitney U test and Spearman\u2019s rank correlation for associations with imaging markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 25 patients with a clinical diagnosis of probable CAA without prior intracerebral hemorrhage and 19 age- and sex-matched controls were included. In patients with CAA, BBB leakage rates were lower in the cortex (4.2 \u00d7 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      \u2009min\n                      <jats:sup>\u22121<\/jats:sup>\n                      vs 5.6 \u00d7 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      \u2009min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ; p\u2009=\u20090.004) and in the white matter (1.2 \u00d7 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      \u2009min\n                      <jats:sup>\u22121<\/jats:sup>\n                      vs 2.1 \u00d7 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      \u2009min\n                      <jats:sup>\u22121<\/jats:sup>\n                      ; p\u2009&lt;\u20090.001) compared with controls. The presence of leptomeningeal enhancement was higher in patients with CAA (68%) compared with controls (47%) (p\u2009=\u20090.007). Within the group with CAA, we did not find a correlation between the number of cortical leakage and cortical CMBs (Spearman\u2019s \u03c1\u2009=\u20090.06, p\u2009=\u20090.79) or the number of foci of leptomeningeal enhancement and cSS hemisphere score (Spearman\u2019s \u03c1\u2009=\u20090.30, p\u2009=\u20090.15).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Our results suggest that global parenchymal gadolinium extravasation across the BBB is lower in patients with CAA compared with controls. This observation can be explained in terms of limited capillary blood perfusion and\/or raising the possibility that vascular amyloid-\u03b2 deposition impairing molecular transport across the BBB. In contrast, focal leptomeningeal enhancement was higher in CAA, reflecting vessel wall infiltration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930261424089","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:35:06Z","timestamp":1770294906000},"page":"1368-1376","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Contrasting patterns of leptomeningeal and parenchymal gadolinium extravasation in cerebral amyloid angiopathy: An MRI-based evaluation"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5182-6676","authenticated-orcid":false,"given":"S","family":"Voigt","sequence":"first","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"},{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJA","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"Mental Health and Neuroscience Research Institute (MHeNs), Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PHM","family":"Voorter","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands"},{"name":"Mental Health and Neuroscience Research Institute (MHeNs), Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-8077","authenticated-orcid":false,"given":"EA","family":"Koemans","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-0997","authenticated-orcid":false,"given":"MR","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MC","family":"van der Plas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-6853","authenticated-orcid":false,"given":"K","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-1376","authenticated-orcid":false,"given":"RGJ","family":"van der Zwet","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-3189","authenticated-orcid":false,"given":"R","family":"van Dort","sequence":"additional","affiliation":[{"name":"Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"van den Brink","sequence":"additional","affiliation":[{"name":"Department of Neurology, J. 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