{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:32:32Z","timestamp":1793017952034,"version":"4.5.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Embolic stroke of undetermined source (ESUS) accounts for up to one quarter of ischemic strokes, with occult atrial fibrillation (AF) as a key underlying cause. Implantable cardiac monitors (ICMs) markedly improve AF detection but are limited by cost and resource demands. Existing AF-prediction models show modest accuracy and lack longitudinal validation. We developed and validated the CATCH-AF score to provide a simple, clinically applicable tool for stratifying early and long-term AF risk after ESUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed 543 consecutive ESUS patients systematically monitored with ICMs. Variable selection used LASSO-penalized Cox regression. Model performance was assessed with time-dependent ROC curves, restricted mean survival time (RMST) analysis, and 10-fold cross-validation. To evaluate geographic generalizability, internal\u2013external cross-validation was performed across seven participating centers, estimating discrimination and calibration for each held-out cohort. Based on the final multivariable model, a point-based score was derived including age, coronary artery disease, heart failure, and prior transient ischemic attack or ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      During 1558.5 patient-years of follow-up, 118 patients (22%) developed new AF. The CATCH-AF score showed excellent discrimination (AUC 0.85, 95% CI 0.82\u20130.89), stable over 4.5\u2009years (0.84\u20130.87). Compared with low-risk patients (0\u20132 points), those at high risk (\u2a7e5 points) had a 19-fold higher hazard of AF detection (HR 19.2, 95% CI 9.4\u201339.4;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and 918 fewer AF-free days (95% CI \u22121080 to \u2212757).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The CATCH-AF score provides a robust, interpretable, and easily applicable tool for predicting AF after ESUS, supporting targeted and cost-effective rhythm monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930261428118","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:20:27Z","timestamp":1771647627000},"page":"946-955","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Atrial fibrillation detection after embolic stroke of undetermined source: Development and validation of the CATCH-AF score"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-3322","authenticated-orcid":false,"given":"Lucio","family":"D\u2019Anna","sequence":"first","affiliation":[{"name":"Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK"},{"name":"Department of Brain Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-6027","authenticated-orcid":false,"given":"Francesco","family":"Favruzzo","sequence":"additional","affiliation":[{"name":"Stroke Unit and Neurosonology Laboratory, Padua University School of Medicine, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Baracchini","sequence":"additional","affiliation":[{"name":"Stroke Unit and Neurosonology Laboratory, Padua University School of Medicine, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pes","sequence":"additional","affiliation":[{"name":"Stroke Unit and Neurosonology Laboratory, Padua University School of Medicine, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fionn","family":"Mag Uidhir","sequence":"additional","affiliation":[{"name":"Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta","family":"Rosin","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Udine University Hospital and Department of Medicine (DAME), University of Udine, Udine, Italy"},{"name":"SOSD Stroke Unit, Department Head, Neck, and Neurosciences, Udine University Hospital, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Valente","sequence":"additional","affiliation":[{"name":"SOSD Stroke Unit, Department Head, Neck, and Neurosciences, Udine University Hospital, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luigi","family":"Gigli","sequence":"additional","affiliation":[{"name":"SOSD Stroke Unit, Department Head, Neck, and Neurosciences, Udine University Hospital, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, St George\u2019s University Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, St George\u2019s University Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manav","family":"Sohal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St George\u2019s University Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sacco","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-4031","authenticated-orcid":false,"given":"Raffaele","family":"Ornello","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-6427","authenticated-orcid":false,"given":"Federico","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubaldo","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-4737","authenticated-orcid":false,"given":"Gabriele","family":"Prandin","sequence":"additional","affiliation":[{"name":"Department of Brain Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Romoli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Tudisco","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica Nicoletta","family":"Sepe","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Barnard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Jeffrey","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Dagan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsering","family":"Dolkar","sequence":"additional","affiliation":[{"name":"Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irtiza","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK"},{"name":"Department of Brain Sciences, Imperial College London, London, 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Laurie","sequence":"additional","affiliation":[{"name":"Comprehensive Stroke Service, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Desai","sequence":"additional","affiliation":[{"name":"Comprehensive Stroke Service, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Haneef","sequence":"additional","affiliation":[{"name":"Comprehensive Stroke Service, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Idian","sequence":"additional","affiliation":[{"name":"Comprehensive Stroke Service, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-3508","authenticated-orcid":false,"given":"Arvind","family":"Chandratheva","sequence":"additional","affiliation":[{"name":"Comprehensive Stroke Service, University College London Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phang Boon","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hammersmith Hospital, Imperial College London NHS Healthcare Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Merlino","sequence":"additional","affiliation":[{"name":"Clinical Neurology, Udine University Hospital and Department of Medicine (DAME), University of Udine, Udine, Italy"},{"name":"SOSD Stroke Unit, Department Head, Neck, and Neurosciences, Udine University Hospital, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0321-7155","authenticated-orcid":false,"given":"Matteo","family":"Foschi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neurology and Stroke Unit, Bufalini Hospital, Cesena, Italy"},{"name":"Department of Neurosciences, Neurology Unit, S.Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Simister","sequence":"additional","affiliation":[{"name":"Comprehensive Stroke Service, University College London Hospital, London, 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value of STAF (Score for the targeting of atrial fibrillation) in patients with cryptogenic embolic stroke","volume":"56","author":"G\u00f6ksu E\u00d6","year":"2019","unstructured":"G\u00f6ksu E\u00d6, Y\u00fcksel B, Esin M, et al. The value of STAF (Score for the targeting of atrial fibrillation) in patients with cryptogenic embolic stroke. Noro Psikiyatr Ars 2019; 56: 119\u2013122.","journal-title":"Noro Psikiyatr Ars"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.01.028"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.04.030"}],"container-title":["International Journal of Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930261428118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17474930261428118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17474930261428118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T19:46:32Z","timestamp":1785008792000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17474930261428118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1177\/17474930261428118"],"URL":"https:\/\/doi.org\/10.1177\/17474930261428118","relation":{},"ISSN":["1747-4930","1747-4949"],"issn-type":[{"value":"1747-4930","type":"print"},{"value":"1747-4949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]}}}