{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:26:07Z","timestamp":1787300767564,"version":"build-2736575974"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"canadian institutes of health research","doi-asserted-by":"publisher","award":["202307"],"award-info":[{"award-number":["202307"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Stroke"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Venous thrombosis and venous thromboembolism (VTE) are important causes and complications of stroke. They may complicate acute stroke as deep venous thrombosis or pulmonary embolism (DVT\/PE), contribute causally to ischemic stroke through paradoxical embolism from a patent foramen ovale (PFO), or present directly as cerebral venous thrombosis (CVT). Despite shared pathophysiological features and overlapping antithrombotic strategies, these conditions are typically considered separately, fragmenting evidence and limiting the exchange of concepts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>We therefore convened experts across both stroke neurology and thrombosis medicine fields to examine these conditions under a unifying venous theme and define priorities for future clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty-two stroke and thrombosis clinicians and researchers identified research priorities across three domains: prevention of VTE after stroke, secondary prevention after PFO-related stroke, and acute and long-term management of CVT. Structured discussions were guided by the PICO (Population, Intervention, Comparison, Outcome) framework, followed by a Delphi survey to establish consensus. Priority questions centered on the balance between thrombosis prevention and bleeding risk and the optimal timing, duration, and choice of DVT\/PE prophylaxis after stroke; the optimal antithrombotic strategy for patients awaiting or forgoing PFO closure; and, for CVT, the role of endovascular therapy in severe disease and the optimal duration of secondary prevention (Graphical Abstract). Across domains, the group prioritized pragmatic and platform trial designs, integration with international registries to address the rarity of CVT, and patient-oriented outcomes that extend beyond functional recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>By considering these venous conditions together and bridging stroke and thrombosis disciplines, this work defines priority questions to address persistent evidence gaps, harmonize practice, and improve patient-centered outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17474930261473348","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T04:32:19Z","timestamp":1784521939000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Venous Thrombotic and Thromboembolic Considerations in Stroke: An Expert Meeting Report on Future Directions for Clinical Trials"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-2971","authenticated-orcid":false,"given":"Diana N","family":"Vikulova","sequence":"first","affiliation":[{"name":"Vancouver Stroke Program, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Dizonno","sequence":"additional","affiliation":[{"name":"Vancouver Stroke Program, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-0864","authenticated-orcid":false,"given":"Lily","family":"Zhou","sequence":"additional","affiliation":[{"name":"Vancouver Stroke Program, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnathon","family":"Gorman","sequence":"additional","affiliation":[{"name":"Vancouver Stroke Program, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-8201","authenticated-orcid":false,"given":"Ronda","family":"Lun","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7263-8474","authenticated-orcid":false,"given":"Katrina HD","family":"Ignacio","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl D","family":"Bushnell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-2070","authenticated-orcid":false,"given":"Aravind","family":"Ganesh","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-0023","authenticated-orcid":false,"given":"Aristedis H","family":"Katsanos","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, McMaster University and Population Health Research Institute, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano A","family":"Sposato","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, Schulich School of Medicine &amp; Dentistry, and Heart &amp; Brain Lab, Western University, London, ON, Canada"},{"name":"Department of Epidemiology &amp; Biostatistics, Schulich School of Medicine &amp; Dentistry, and Heart &amp; Brain Lab, Western University, London, ON, Canada"},{"name":"Department of Anatomy and Cell Biology, Schulich School of Medicine &amp; Dentistry, and Heart &amp; Brain Lab, Western University, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-1446","authenticated-orcid":false,"given":"Sara DB","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Lisbon Central University Hospital\u2013S\u00e3o Jos\u00e9 Local Health Unit, Lisbon, Portugal"},{"name":"Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Fuerte-Hortigon","sequence":"additional","affiliation":[{"name":"Vancouver Stroke Program, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-7924","authenticated-orcid":false,"given":"Diana","family":"Aguiar de Sousa","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Stroke Center, Department of Neurosciences, Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8942-953X","authenticated-orcid":false,"given":"Cheryl","family":"Carcel","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-0904","authenticated-orcid":false,"given":"Nishita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Neurology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9981-8990","authenticated-orcid":false,"given":"Bethany T","family":"Samuelson Bannow","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; 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