{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:30:12Z","timestamp":1777944612511,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Perioperative Practice"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>The incidence rates of spinal anaesthesia-induced hypotension vary depending on the surgical procedures. This systematic review and meta-analysis evaluates the efficacy of prophylactic ondansetron in reducing the incidence of spinal anaesthesia-induced hypotension in non-caesarean delivery. Thirteen trials consisting of 1166 patients were included for analysis. Compared to placebo, there is a low quality of evidence that ondansetron was effective in reducing the incidence of spinal anaesthesia-induced hypotension (RR 0.62, 95% CI 0.44 to 0.87; p\u2009=\u20090.005) and bradycardia (RR 0.54, 95% CI 0.32 to 0.90; p\u2009=\u20090.02). We also found a moderate quality of evidence that ondansetron lowered the number of rescue ephedrine (RR 0.61, 95% CI 0.43 to 0.87; p\u2009=\u20090.007). Patients treated with ondansetron have higher mean arterial pressure 15 to 20 minutes after spinal anaesthesia induction and higher systolic arterial pressure 5, 10, 15 and 20 minutes after spinal anaesthesia. The evidence suggests that prophylactic administration of ondansetron results in the reduction of the incidence of spinal anaesthesia-induced hypotension, bradycardia and rescue ephedrine in patients undergoing non-caesarean delivery under spinal anaesthesia.<\/jats:p>","DOI":"10.1177\/1750458920964157","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T11:25:07Z","timestamp":1613647507000},"page":"29-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Ondansetron reduces the incidence of hypotension after spinal anaesthesia in non-caesarean delivery: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-0039","authenticated-orcid":false,"given":"Tito","family":"D Tubog","sequence":"first","affiliation":[{"name":"Graduate Programs of Nurse Anesthesia, Texas Wesleyan University, Fort Worth, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"S Bramble","sequence":"additional","affiliation":[{"name":"O'Connor Hospital, San Jose, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"issue":"4","key":"bibr1-1750458920964157","first-page":"208","volume":"6","author":"Baig R","year":"2017","journal-title":"Journal of Islamabad Medical & Dental College"},{"key":"bibr2-1750458920964157","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-018-0640-3"},{"key":"bibr3-1750458920964157","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200305000-00030"},{"issue":"8","key":"bibr4-1750458920964157","first-page":"CD002251","volume":"8","author":"Chooi C","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"bibr5-1750458920964157","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2015.08.012"},{"key":"bibr6-1750458920964157","doi-asserted-by":"publisher","DOI":"10.1097\/01.aoa.0000515776.35920.1e"},{"key":"bibr7-1750458920964157","unstructured":"Higgins JP, Green S 2011 Guide to the Contents of a Cochrane Protocol and Review. 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