{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:28:05Z","timestamp":1777944485765,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Perioperative Practice"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Local anaesthetic systemic toxicity is a life-threatening adverse event that may occur after administration of local anaesthetics through a variety of routes. Local anaesthetic systemic toxicity is always a potential complication and may occur with all local anaesthetics and in any route of administration. Local anaesthetic systemic toxicity primarily affects the central nervous system and the cardiovascular system and may be fatal. The following is a case of local anaesthetic systemic toxicity complicating surgeon-performed intraoperative intercostal nerve blocks at multiple levels, with a mixture of liposomal bupivacaine and bupivacaine hydrochloride in a patient who underwent video-assisted segmental lung resection for lung cancer under general anaesthesia. Local anaesthetic systemic toxicity presented with seizures and hypotension. The patient was successfully managed and fully recovered. This case illustrates the importance of awareness regarding the prevention, diagnosis and treatment of local anaesthetic systemic toxicity among medical professionals who administer local anaesthetics.<\/jats:p>","DOI":"10.1177\/17504589231180769","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:38:11Z","timestamp":1690850291000},"page":"390-395","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Local anaesthetic systemic toxicity complicating intraoperative intercostal nerve blocks: What do clinicians need to know to prevent similar occurrence?"],"prefix":"10.1177","volume":"33","author":[{"given":"Mafdy N","family":"Basta","sequence":"first","affiliation":[{"name":"Department of Anesthesiology & Perioperative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"bibr1-17504589231180769","unstructured":"Association of Anaesthetists of Great Britain and Ireland) not dated Safety guideline: Management of severe local anesthetic toxicity Available at https:\/\/www.aagbi.org\/sites\/default\/files\/la_toxicity_2010_0.pdf [Accessed April 2016]"},{"key":"bibr2-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1335304"},{"key":"bibr3-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e318292669b"},{"key":"bibr4-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31826c330a"},{"key":"bibr5-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X14543102"},{"key":"bibr6-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-015-0564-z"},{"key":"bibr7-17504589231180769","doi-asserted-by":"publisher","DOI":"10.2147\/LRA.S154512"},{"key":"bibr8-17504589231180769","unstructured":"Exparel (not dated) Available at https:\/\/www.exparel.com\/sites\/default\/files\/EXPAREL_PI_Nerve_Block_Final_4-6-2018.pdf [Accessed June 2018]"},{"key":"bibr9-17504589231180769","unstructured":"FDA (not dated) Available at https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/022496s9lbl.pdf"},{"key":"bibr10-17504589231180769","volume-title":"Local Anesthetics: Clinical Pharmacology and Rational Selection","author":"Gadsden J","year":"2013"},{"issue":"2","key":"bibr11-17504589231180769","first-page":"124","volume":"43","author":"Gitman M","year":"2018","journal-title":"Regional Anesthesia & Pain Medicine"},{"key":"bibr12-17504589231180769","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1115515"},{"key":"bibr13-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-012-0043-z"},{"key":"bibr14-17504589231180769","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1004582"},{"key":"bibr15-17504589231180769","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161030-00002"},{"key":"bibr16-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000544"},{"key":"bibr17-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000720"},{"key":"bibr18-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101986"},{"key":"bibr19-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2014.07.040"},{"key":"bibr20-17504589231180769","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000334"}],"container-title":["Journal of Perioperative Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17504589231180769","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17504589231180769","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17504589231180769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:05:41Z","timestamp":1777709141000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17504589231180769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/17504589231180769"],"URL":"https:\/\/doi.org\/10.1177\/17504589231180769","relation":{},"ISSN":["1750-4589","2515-7949"],"issn-type":[{"value":"1750-4589","type":"print"},{"value":"2515-7949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]}}}