{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:32:09Z","timestamp":1777944729738,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Perioperative Practice"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We conducted this study to compare the efficacy of oral 10 and 5\u2009mg olanzapine for the prevention of postoperative nausea and vomiting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Notably, 135 female patients between the ages of 18 and 50\u2009years, classed as American Society of Anaesthesiologists I and II, who underwent elective laparoscopic gynaecological surgery under general anaesthesia were randomly assigned to one of three groups (45 each) to receive perioperative 5 or 10\u2009mg oral olanzapine (OL5 and OL10 groups), or a placebo (in the control group). Postoperation, we recorded the occurrence and severity of postoperative nausea and vomiting within 24\u2009h, the number of patients who received antiemetics and any associated side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Postoperative nausea was more prevalent in the control group (23 patients) than in OL5 and OL10 groups (13 and three patients, respectively); Group OL10 had the lowest severity of nausea. There was no incidence of vomiting in the OL10 group, and only one patient required antiemetics; in the OL5 group, three patients required antiemetics and eight patients in the control group needed antiemetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Olanzapine 10\u2009mg had a higher effect than the lower concentration of 5\u2009mg or control in reducing the incidence of postoperative nausea and vomiting in the first postoperative 24\u2009h.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17504589241308820","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T21:51:27Z","timestamp":1738101087000},"page":"293-299","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of different doses of oral olanzapine to prevent postoperative nausea and vomiting after laparoscopic surgery in high-risk patients: A randomised controlled trial"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6828-4618","authenticated-orcid":false,"given":"Amani H","family":"Abdel-Wahab","sequence":"first","affiliation":[{"name":"Department of Anaethesia, Intensive Care and Pain Management Department, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada M","family":"Abo Elfad","sequence":"additional","affiliation":[{"name":"Department of Anaethesia, Intensive Care and Pain Management Department, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mohamed","family":"Aboelfadl","sequence":"additional","affiliation":[{"name":"Department of Anaethesia, Intensive Care and Pain Management, Military Medical Academy, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Bahloul","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology Department, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa Mahmoud","family":"Abdel Rady","sequence":"additional","affiliation":[{"name":"Department of Anaethesia, Intensive Care and Pain Management Department, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032196"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(94)00129-N"},{"issue":"6","key":"e_1_3_3_4_1","first-page":"649","article-title":"Betahistine reduces postoperative nausea and vomiting after laparoscopic gynaecological surgery","volume":"82","author":"Cho JS","year":"2016","unstructured":"Cho JS, Kim EJ, Lee JH, et al 2016 Betahistine reduces postoperative nausea and vomiting after laparoscopic gynaecological surgery Minerva Anestesiol 82 (6) 649\u2013656.","journal-title":"Minerva Anestesiol"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13064"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2000.440422.x"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03012088"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.10.1233"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004833"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16081"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30678-3"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200004000-00012"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2138-y"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000003286"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003990"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-021-01045-z"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1103900405"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/175045891702701004"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464230-00006"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.05.003"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-004-0755-6"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1515725"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-200029066"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq194"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-020-00559-4"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-28-131"},{"key":"e_1_3_3_27_1","unstructured":"Thomas KSA 2023 Olanzapine Treasure Island FL StatPearls Publishing. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532903\/"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2019.08.04"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2004.05.003"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15295"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0378"}],"container-title":["Journal of Perioperative Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17504589241308820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17504589241308820","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17504589241308820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:06:54Z","timestamp":1777709214000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17504589241308820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,26]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/17504589241308820"],"URL":"https:\/\/doi.org\/10.1177\/17504589241308820","relation":{},"ISSN":["1750-4589","2515-7949"],"issn-type":[{"value":"1750-4589","type":"print"},{"value":"2515-7949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,26]]}}}