{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:07:01Z","timestamp":1777950421010,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Perioperative Practice"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Venous thromboembolism is the leading cause of postoperative death in patients undergoing oncological surgery. This systematic review and meta-analysis compares the efficacy of low-molecular-weight heparin with direct oral anticoagulants in preventing venous thromboembolism in major abdominopelvic surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This systematic review was conducted according to a predefined protocol registered in PROSPERO (ID: 1307005) and is reported in accordance with the PRISMA 2020 statement. A search was conducted in the Cochrane Library, PubMed Central\/Medline, and Google Scholar from 2000 until September 2024. The analysis was performed using RevMan 5.4.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of seven studies were included. There was no significant difference in incidence of venous thromboembolism (Risked Ratio\u2009=\u20091.77, p\u2009=\u20090.08), major bleeding events (RR\u2009=\u20090.60, p\u2009=\u20090.51), or pulmonary embolism incidence (Risked Ratio\u2009=\u20093.38, p\u2009=\u20090.17) among the seven included studies. A subgroup analysis of five studies performed for incidence of venous thromboembolism in gynaecological procedures also showed an insignificant difference between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Direct oral anticoagulants offer efficacy and safety comparable to low-molecular-weight heparins. Further large-scale randomised controlled trials are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17504589261440451","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:46:54Z","timestamp":1777571214000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of low molecular weight heparins with direct oral anticoagulants for the prevention of venous thromboembolism in major abdominopelvic surgeries: A systematic review and meta-analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-2975","authenticated-orcid":false,"given":"Shajie Ur Rehman","family":"Usmani","sequence":"first","affiliation":[{"name":"Dow University of Health Sciences, Karachi, 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