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We present a patient who developed antenatal necrotising myometritis and toxic shock syndrome (TSS) due to GAS during the first trimester of pregnancy, eventually requiring hysterectomy and bilateral oophorectomy. We discuss the rare complication of ante-partum necrotising myometritis, as well as the antibiotic therapy, and treatment of TSS associated with severe Group A Streptococcal infections.<\/jats:p>","DOI":"10.1177\/1751143714565855","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T23:27:06Z","timestamp":1421105226000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ante-partum necrotising myometritis due to Streptococcal toxic shock"],"prefix":"10.1177","volume":"16","author":[{"given":"Sanjay","family":"Tarvade","sequence":"first","affiliation":[{"name":"Staff Specialist in Intensive Care Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S","family":"Lane","sequence":"additional","affiliation":[{"name":"Senior Lecturer in Intensive Care Medicine, Sydney Medical School, Sydney, NSW, Australia"},{"name":"Staff Specialist in Intensive Care Medicine, Nepean Hospital, Sydney, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,12]]},"reference":[{"key":"bibr1-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00900.x"},{"key":"bibr2-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1155\/S1064744900000302"},{"key":"bibr3-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1155\/S1064744999000514"},{"key":"bibr4-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1086\/342062"},{"key":"bibr5-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir325"},{"key":"bibr6-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90043-5"},{"key":"bibr7-1751143714565855","first-page":"153","volume":"94","author":"Udagawa H","year":"1999","journal-title":"Obstet Gynecol"},{"key":"bibr8-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199406000-00033"},{"key":"bibr9-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500030088038"},{"key":"bibr10-1751143714565855","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.72.258"},{"key":"bibr11-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907063210101"},{"key":"bibr12-1751143714565855","doi-asserted-by":"publisher","DOI":"10.1155\/S1064744902000248"},{"key":"bibr13-1751143714565855","first-page":"547","volume":"335","author":"Davies HD","year":"1996","journal-title":"Ontario Group A Streptococcal Study Group. 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