{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:51:00Z","timestamp":1791197460558,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Intensive Care Society"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>The acute central nervous system infections meningitis and encephalitis commonly require management on intensive care units. The clinical features often overlap and in the acute phase\u2013altered consciousness and seizures may also need to be managed. In April 2012, the first UK national guideline for the management of suspected viral encephalitis was published by the British Infection Association and Association of British Neurologists, and other key stakeholders, and included a simple management algorithm. The new guideline results from evidence demonstrating a number of common oversights in the standard management of suspected viral encephalitis in many settings. In combination with British Infection Association meningitis guidelines, evidence-based approaches now exist to facilitate the non-expert managing patients with suspected central nervous system infections. Here we bring together these guidelines and the supporting evidence applicable for intensivists into a single resource.<\/jats:p>","DOI":"10.1177\/1751143715587927","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T22:41:08Z","timestamp":1432852868000},"page":"330-338","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Managing acute central nervous system infections in the UK adult intensive care unit in the wake of UK encephalitis guidelines"],"prefix":"10.1177","volume":"16","author":[{"given":"DJ","family":"Stoeter","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Royal Liverpool University Hospital, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BD","family":"Michael","sequence":"additional","affiliation":[{"name":"Institute of Infection and Global Health, and NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, UK"},{"name":"Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Solomon","sequence":"additional","affiliation":[{"name":"Institute of Infection and Global Health, and NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, UK"},{"name":"Walton Centre NHS Foundation Trust, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Royal Liverpool University Hospital, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"bibr1-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-011-0086-5"},{"key":"bibr2-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052116"},{"key":"bibr3-1751143715587927","first-page":"1327","volume-title":"Brain\u2019s diseases of the nervous system","author":"Solomon T","year":"2011"},{"key":"bibr4-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70222-X"},{"key":"bibr5-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2013.03.011"},{"key":"bibr6-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldh057"},{"key":"bibr7-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.129098"},{"key":"bibr8-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2011.11.014"},{"key":"bibr9-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcq121"},{"key":"bibr10-1751143715587927","doi-asserted-by":"publisher","DOI":"10.3201\/eid1909.130064"},{"key":"bibr11-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hci047"},{"key":"bibr12-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.3.321"},{"key":"bibr13-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1086\/341405"},{"key":"bibr14-1751143715587927","first-page":"533","volume":"255","author":"Kennedy PGE","year":"1988","journal-title":"Q J Med"},{"key":"bibr15-1751143715587927","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.9-3-231"},{"key":"bibr16-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827e83af"},{"key":"bibr17-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.10.663"},{"key":"bibr18-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldh057"},{"key":"bibr19-1751143715587927","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.04.002"},{"key":"bibr20-1751143715587927","unstructured":"National Institute of Clinical Excellence. 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