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Cytosorb was used in these patients to remove bilirubin and bile acids by supporting impaired excretory hepatic function, alleviating symptoms with the intention of serving as a bridge to endogenous recovery. The first two cases demonstrate favourable biochemical and symptomatic responses; the third case demonstrated a good biochemical response but subsequently died from the complications of multiple organ failure. These cases suggest Cytosorb\u2122 be evaluated as an adjunct to support liver excretory functions in other arenas, such as acute liver failure or overdose. It remains unclear whether extracorporeal therapies removing liver toxins allow faster or more complete spontaneous recovery of endogenous function.<\/jats:p>","DOI":"10.1177\/1751143718772789","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T02:49:15Z","timestamp":1527562155000},"page":"174-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Novel use of Cytosorb\u2122 haemadsorption to provide biochemical control in liver impairment"],"prefix":"10.1177","volume":"20","author":[{"given":"VD","family":"Dhokia","sequence":"first","affiliation":[{"name":"University Hospitals Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Royal Derby Hospital, Derby, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Austin","sequence":"additional","affiliation":[{"name":"Royal Derby Hospital, Derby, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig G","family":"Morris","sequence":"additional","affiliation":[{"name":"Royal Derby Hospital, Derby, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"bibr1-1751143718772789","unstructured":"http:\/\/cytosorb-therapy.com\/ (accessed 3 October 2017)."},{"key":"bibr2-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1177\/1751143715574855"},{"key":"bibr3-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1662-9"},{"key":"bibr4-1751143718772789","unstructured":"https:\/\/www.nice.org.uk\/advice\/mib87\/ (2016, accessed 30 September 2017)."},{"key":"bibr5-1751143718772789","unstructured":"http:\/\/www.cytosorb-registry.org\/publikationen-2\/?lang=en (accessed 3 October 2017)."},{"key":"bibr6-1751143718772789","unstructured":"http:\/\/vitaltherapies.com\/elad\/technology\/ (accessed 03 October 2017)."},{"key":"bibr7-1751143718772789","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000489"},{"key":"bibr8-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1159\/000470826"},{"key":"bibr9-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050107"},{"key":"bibr10-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02587.x"},{"key":"bibr11-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312670"},{"key":"bibr12-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1186\/cc10424"},{"key":"bibr13-1751143718772789","unstructured":"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02654327 (accessed 3 October 2017)."},{"key":"bibr14-1751143718772789","unstructured":"https:\/\/www.organ-assist.nl\/products\/liver-assist (accessed 3 October 2017)."},{"key":"bibr15-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412278"},{"key":"bibr16-1751143718772789","first-page":"CD005162","volume":"9","author":"Gludd LL","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr17-1751143718772789","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907893"},{"key":"bibr18-1751143718772789","doi-asserted-by":"publisher","DOI":"10.4161\/org.7.1.14069"},{"key":"bibr19-1751143718772789","unstructured":"Extracorporeal albumin dialysis for acute liver failure. 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