{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:07:29Z","timestamp":1793930849658,"version":"4.8.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NI HSC R&D Division","award":["EAT\/5103\/14"],"award-info":[{"award-number":["EAT\/5103\/14"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Intensive Care Society"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Accumulation of a positive fluid balance is common in critically ill patients, and is associated with adverse outcomes, including mortality. However, there are few randomised clinical trials to guide clinicians as to the most appropriate fluid strategy following initial resuscitation and on the use of deresuscitation (removal of accumulated fluid using diuretics and\/or renal replacement therapy). To inform the design of randomised trials, we surveyed critical care physicians with regard to perceptions of fluid overload in critical care, self-reported practice, acceptability of a variety of approaches to deresuscitation, appropriate safety parameters, and overall acceptability of a randomised trial of deresuscitation. Of 524 critical care specialists completing the survey, the majority practiced in mixed medical\/surgical intensive care units in the United Kingdom. Most (309 of 363 respondents, 85%) believed fluid overload to be a modifiable source of morbidity; there was strong support (395 of 457, 86%) for a randomised trial of deresuscitation in critical illness. Marked practice variability was evident among respondents. In a given clinical scenario, self-reported practice ranged from the administration of fluid (N\u2009=\u200959, 14%) to the administration of a diuretic (N\u2009=\u2009285, 67%). The majority (95%) considered it appropriate to administer diuretics for fluid overload in the setting of noradrenaline infusion and to continue to administer diuretics despite mild dysnatraemias, hypotension, metabolic alkalosis, and hypokalaemia. The majority of critical care physicians view fluid overload as a common and modifiable source of morbidity; deresuscitation is widely practiced, and there is widespread support for randomised trials of deresuscitation in critical illness.<\/jats:p>","DOI":"10.1177\/1751143719846442","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T06:23:39Z","timestamp":1557728619000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":51,"title":["Fluid management and deresuscitation practices: A survey of critical care physicians"],"prefix":"10.1177","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3183-4337","authenticated-orcid":false,"given":"Jonathan A","family":"Silversides","sequence":"first","affiliation":[{"name":"Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK"},{"name":"Department of Critical Care Services, Belfast Health and Social Care Trust, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F","family":"McAuley","sequence":"additional","affiliation":[{"name":"Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK"},{"name":"Department of Critical Care Services, Belfast Health and Social Care Trust, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronagh","family":"Blackwood","sequence":"additional","affiliation":[{"name":"Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Fan","sequence":"additional","affiliation":[{"name":"Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK"},{"name":"Department of Critical Care Services, Belfast Health and Social Care Trust, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Marshall","sequence":"additional","affiliation":[{"name":"Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada"},{"name":"Department of Critical Care Medicine, St Michael's Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"bibr1-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003276"},{"key":"bibr2-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2706"},{"key":"bibr3-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1186\/cc6916"},{"key":"bibr4-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0970-1"},{"key":"bibr5-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1186\/cc11682"},{"key":"bibr6-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"bibr7-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000171539.47006.02"},{"key":"bibr8-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1525"},{"key":"bibr9-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4573-3"},{"key":"bibr10-1751143719846442","doi-asserted-by":"crossref","unstructured":"Ng KT, Velayit A, Khoo DKY, et al. Continuous Infusion versus Intermittent Bolus Injection of Furosemide in Critically Ill Patients: A Systematic Review and Meta-analysis.\n                      J Cardiothorac Vasc Anesth\n                      2018; 32: 2303\u20132310.","DOI":"10.1053\/j.jvca.2018.01.004"},{"key":"bibr11-1751143719846442","doi-asserted-by":"crossref","unstructured":"Bihari S, Holt AW, Prakash S, et al. Addition of indapamide to frusemide increases natriuresis and creatinine clearance, but not diuresis, in fluid overloaded ICU patients.\n                      J Crit Care\n                      2016; 33: 200\u2013206.","DOI":"10.1016\/j.jcrc.2016.01.017"},{"key":"bibr12-1751143719846442","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu300"},{"key":"bibr13-1751143719846442","doi-asserted-by":"crossref","unstructured":"McIntyre L, Rowe BH, Walsh TS, et al. Multicountry survey of emergency and critical care medicine physicians\u00e3 fluid resuscitation practices for adult patients with early septic shock.\n                      BMJ Open\n                      2016; 6: e010041.","DOI":"10.1136\/bmjopen-2015-010041"},{"key":"bibr14-1751143719846442","doi-asserted-by":"crossref","unstructured":"Glassford NJ, M\u00e5rtensson J, Eastwood G, et al. Defining the characteristics and expectations of fluid bolus therapy: A worldwide perspective.\n                      J Crit Care\n                      2016; 35: 126\u2013132.","DOI":"10.1016\/j.jcrc.2016.05.017"},{"key":"bibr15-1751143719846442","doi-asserted-by":"crossref","unstructured":"O'Connor ME, Jones SL, Glassford NJ, et al. Defining fluid removal in the intensive care unit: A national and international survey of critical care practice.\n                      J Intensive Care Soc\n                      2017; 18: 282\u2013288.","DOI":"10.1177\/1751143717699423"}],"container-title":["Journal of the Intensive Care Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1751143719846442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1751143719846442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1751143719846442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:53:58Z","timestamp":1777460038000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1751143719846442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,13]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1177\/1751143719846442"],"URL":"https:\/\/doi.org\/10.1177\/1751143719846442","relation":{},"ISSN":["1751-1437"],"issn-type":[{"value":"1751-1437","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,13]]}}}