{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:15:10Z","timestamp":1787019310691,"version":"build-2736575974"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["Institutional Strategic Support Fund-3 (ISR-R1.05"],"award-info":[{"award-number":["Institutional Strategic Support Fund-3 (ISR-R1.05"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Intensive Care Society"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Many people survive critical illness with the burden of new or worsened mental health issues and sleep disturbances. We examined the frequency of psychotropic prescribing after critical illness, comparing critical care to non-critical care hospitalised survivors, and whether this varied in important subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study included 23,340 critical care and 367,185 non-critical care hospitalised adults from 2012 through 2019 in Lothian, Scotland, who survived to discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One-third of critical care survivors (32%; 7527\/23,340) received a psychotropic prescription within 90\u2009days after hospital discharge (25% antidepressants; 14% anxiolytics\/hypnotics; 4% antipsychotics\/mania medicines). In contrast, 15% (54,589\/367,185) of non-critical care survivors received a psychotropic prescription (12% antidepressants; 5% anxiolytics\/hypnotics; 2% antipsychotics\/mania medicines). Among patients without psychotropic prescriptions within 180\u2009days prior to hospitalisation, after hospital discharge, the critical care group had a higher incidence of psychotropic prescription (10.3%; 1610\/15,609) compared with the non-critical care group (3.2%; 9743\/307,429); unadjusted hazard ratio (HR) 3.39, 95% CI: 3.22\u20133.57. After adjustment for potential confounders, the risk remained elevated (adjusted HR 2.03, 95% CI: 1.91\u20132.16), persisted later in follow-up (90\u2013365\u2009days; adjusted HR 1.38, 95% CI: 1.30\u20131.46), and was more pronounced in those without recorded comorbidities (adjusted HR 3.49, 95% CI: 3.22\u20133.78).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Critical care survivors have a higher risk of receiving psychotropic prescriptions than hospitalised patients, with a significant proportion receiving benzodiazepines and other hypnotics. Future research should focus on the requirement for and safety of psychotropic medicines in survivors of critical illness, to help guide policy for clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17511437231223470","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T03:56:29Z","timestamp":1705636589000},"page":"171-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Psychotropic prescribing after hospital discharge in survivors of critical illness, a retrospective cohort study (2012\u20132019)"],"prefix":"10.1177","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-3752","authenticated-orcid":false,"given":"Elizabeth T","family":"Mansi","sequence":"first","affiliation":[{"name":"Usher Institute, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK"},{"name":"Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S","family":"Bourne","sequence":"additional","affiliation":[{"name":"Departments of Pharmacy and Critical Care, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"},{"name":"Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Guthrie","sequence":"additional","affiliation":[{"name":"Usher Institute, University of Edinburgh, Edinburgh, UK"},{"name":"Advanced Care Research Centre, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-2779","authenticated-orcid":false,"given":"Nazir I","family":"Lone","sequence":"additional","affiliation":[{"name":"Usher Institute, University of Edinburgh, Edinburgh, UK"},{"name":"Department of Anaesthesia, Critical Care, and Pain Medicine, School of Clinical Sciences, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"bibr1-17511437231223470","unstructured":"ICNARC \u2013 Reports [Internet], https:\/\/www.icnarc.org\/Our-Audit\/Audits\/Cmp\/Reports (accessed 11 May 2022)."},{"key":"bibr2-17511437231223470","unstructured":"SICSAG about [Internet], https:\/\/www.sicsag.scot.nhs.uk\/about\/main.html (accessed 22 May 2022)."},{"key":"bibr3-17511437231223470","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001811"},{"key":"bibr4-17511437231223470","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2016.08.005"},{"key":"bibr5-17511437231223470","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000882"},{"key":"bibr6-17511437231223470","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2223-6"},{"key":"bibr7-17511437231223470","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2014.11.002"},{"key":"bibr8-17511437231223470","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S193084"},{"key":"bibr9-17511437231223470","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201702-148SR"},{"key":"bibr10-17511437231223470","unstructured":"National Records of Scotland Web. 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