{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:39:20Z","timestamp":1788986360647,"version":"build-2803163510"},"reference-count":9,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["P72892 Research Contract to Imperial College Londo"],"award-info":[{"award-number":["P72892 Research Contract to Imperial College Londo"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Intensive Care Society"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There are theoretical reasons why beta-lactam antibiotics may be more effective in treating severe infections if administered by continuous infusion, rather than short intermittent infusions. The Beta-Lactam Infusion Group (BLING) III trial was a multinational randomised clinical trial (RCT) which tested this hypothesis in participants with sepsis who were cared for in an intensive care unit (ICU). The United Kingdom (UK) findings are reported here.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The global trial was an open-label RCT conducted in the UK, Australia, New Zealand, Belgium, France, Sweden and Malaysia. Participants were critically ill adults being treated with meropenem or piperacillin\/tazobactam due to a confirmed or presumed infection. Participants were randomised to receive the antibiotic by either continuous infusion or short intermittent infusion at equivalent daily doses as selected by the treating team. The primary outcome was 90-day all-cause mortality; secondary outcomes included clinical cure up to 14\u2009days after randomisation, new infection and acquisition of resistant organisms, ICU and in hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Overall, 7202 participants were randomised, with 2900 from the UK. The UK cohort had very similar baseline characteristics and outcomes to the global trial. For continuous versus intermittent infusion, the global trial showed 24.9% versus 26.8% participants had died by 90\u2009days (odds ratio 0.91, 95% CI: 0.81\u20131.01,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.08); and in the UK 26.7% versus 29.3% participants had died (odds ratio 0.88, 95% CI: 0.75\u20131.04,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.13). Although not statistically significant, all outcomes showed point estimates in favour of continuous infusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The findings in the UK cohort are consistent with the conclusions drawn from the global BLING III trial. It seems reasonable to conclude the finding are applicable to the UK.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17511437251396871","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:36:22Z","timestamp":1764311782000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous versus intermittent beta-lactam antibiotic infusions in critically ill patients: The UK cohort of the BLING III trial"],"prefix":"10.1177","volume":"27","author":[{"given":"Janis","family":"Best-Lane","sequence":"first","affiliation":[{"name":"Imperial Clinical Trials Unit, Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Al-Beidh","sequence":"additional","affiliation":[{"name":"Imperial Clinical Trials Unit, Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-1734","authenticated-orcid":false,"given":"Greg","family":"Barton","sequence":"additional","affiliation":[{"name":"Mersey and West Lancashire Teaching Hospitals NHS Trust, Prescot, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorrilyn","family":"Rajbhandari","sequence":"additional","affiliation":[{"name":"Critical Care Program, The George Institute for Global Health, UNSW Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8620-6592","authenticated-orcid":false,"given":"Xiaoqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Critical Care Program, The George Institute for Global Health, UNSW Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi","family":"Mysore","sequence":"additional","affiliation":[{"name":"Critical Care Program, The George Institute for Global Health, UNSW Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5028-3825","authenticated-orcid":false,"given":"Serena","family":"Knowles","sequence":"additional","affiliation":[{"name":"Critical Care Program, The George Institute for Global Health, UNSW Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Hammond","sequence":"additional","affiliation":[{"name":"Critical Care Program, The George Institute for Global Health, UNSW Sydney, Australia"},{"name":"Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, St Leonards, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Dulhunty","sequence":"additional","affiliation":[{"name":"University of Queensland, Brisbane, Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital, QLD, Australia"},{"name":"Redcliffe Hospital, Brisbane, QLD, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-7016","authenticated-orcid":false,"given":"John","family":"Myburgh","sequence":"additional","affiliation":[{"name":"Critical Care Program, The George Institute for Global Health, UNSW Sydney, Australia"},{"name":"St George Hospital, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-9876","authenticated-orcid":false,"given":"Jeffrey","family":"Lipman","sequence":"additional","affiliation":[{"name":"University of Queensland, Brisbane, Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital, QLD, Australia"},{"name":"Jamieson Trauma Institute, Brisbane, QLD, Australia"},{"name":"Division of Anesthesia, Critical Care, Emergency and Pain Medicine, University of Montpellier, N\u00eemes University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-8413","authenticated-orcid":false,"given":"Stephen J.","family":"Brett","sequence":"additional","affiliation":[{"name":"Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, UK"},{"name":"Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.9779"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.02.002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis856"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201505-0857OC"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.9803"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.10168"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1441-2772(23)00582-3"},{"issue":"3","key":"e_1_3_2_9_2","first-page":"273","article-title":"Statistical analysis plan for the BLING III study: a phase 3 multicentre randomised controlled trial of continuous versus intermittent \u03b2-lactam antibiotic infusion in critically ill patients with sepsis","volume":"23","author":"Billot L","year":"2023","unstructured":"Billot L, Lipman J, Brett SJ, et al. Statistical analysis plan for the BLING III study: a phase 3 multicentre randomised controlled trial of continuous versus intermittent \u03b2-lactam antibiotic infusion in critically ill patients with sepsis. Crit Care Resus 2023; 23(3): 273\u2013284.","journal-title":"Crit Care Resus"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07724-w"}],"container-title":["Journal of the Intensive Care Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17511437251396871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17511437251396871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17511437251396871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:55:31Z","timestamp":1777460131000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17511437251396871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/17511437251396871"],"URL":"https:\/\/doi.org\/10.1177\/17511437251396871","relation":{},"ISSN":["1751-1437","1751-1437"],"issn-type":[{"value":"1751-1437","type":"print"},{"value":"1751-1437","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]}}}