{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:44:42Z","timestamp":1784220282357,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T00:00:00Z","timestamp":1224460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>Dupuytren\u2019s disease is characterised by nodular fibroblastic proliferation of the palmar fascia leading to contracture of the hand. Transforming growth factor beta (TGF- \u03b2) is thought to play a role in its pathogenesis. We performed a cDNA microarray analysis of Dupuytren\u2019s diseased cord tissue with an emphasis on TGF- \u03b2 isoforms. Normal-appearing transverse ligament of the palmar fascia from adjacent to the diseased cord and palmar fascia from patients undergoing carpal tunnel release were used as controls. TGF- \u03b2 gene expression was confirmed by quantitative real-time polymerase chain reaction. Over 20 unique genes were found to be significantly up-regulated, including several previously reported genes. A dominant increase in TGF- \u03b22 expression was seen in the cord tissue, whereas TGF- \u03b21 and TGF- \u03b23 were found not to be significantly up-regulated. Quantitative real-time polymerase chain reaction confirmed these findings. This gene expression profile allows for further experiments that may eventually lead to gene therapy to block the development and progression of Dupuytren\u2019s disease clinically.<\/jats:p>","DOI":"10.1177\/1753193408091352","type":"journal-article","created":{"date-parts":[[2008,8,11]],"date-time":"2008-08-11T20:33:41Z","timestamp":1218486821000},"page":"783-790","source":"Crossref","is-referenced-by-count":24,"title":["Gene Expression Analysis of Dupuytren\u2019s Disease: The Role of                   TGF-\n                    <i>\u03b2<\/i>\n                    2"],"prefix":"10.1177","volume":"33","author":[{"given":"A. Y.","family":"ZHANG","sequence":"first","affiliation":[{"name":"From the Division of Plastic Surgery, Stanford Hospital and\r               Clinics, Stanford, CA and the Division of Plastic Surgery, Veteran\u2019s Affairs Palo\r               Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. D.","family":"FONG","sequence":"additional","affiliation":[{"name":"From the Division of Plastic Surgery, Stanford Hospital and\r               Clinics, Stanford, CA and the Division of Plastic Surgery, Veteran\u2019s Affairs Palo\r               Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"PHAM","sequence":"additional","affiliation":[{"name":"From the Division of Plastic Surgery, Stanford Hospital and\r               Clinics, Stanford, CA and the Division of Plastic Surgery, Veteran\u2019s Affairs Palo\r               Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. P.","family":"NACAMULI","sequence":"additional","affiliation":[{"name":"From the Division of Plastic Surgery, Stanford Hospital and\r               Clinics, Stanford, CA and the Division of Plastic Surgery, Veteran\u2019s Affairs Palo\r               Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"LONGAKER","sequence":"additional","affiliation":[{"name":"From the Division of Plastic Surgery, Stanford Hospital and\r               Clinics, Stanford, CA and the Division of Plastic Surgery, Veteran\u2019s Affairs Palo\r               Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"CHANG","sequence":"additional","affiliation":[{"name":"From the Division of Plastic Surgery, Stanford Hospital and\r               Clinics, Stanford, CA and the Division of Plastic Surgery, Veteran\u2019s Affairs Palo\r               Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,10,20]]},"reference":[{"key":"b1-0330783","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.12.3324"},{"key":"b2-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(94)90059-0"},{"key":"b3-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(96)80102-X"},{"key":"b4-0330783","first-page":"499","volume":"53","author":"Bailey AJ","year":"1977","journal-title":"Clinical Science and Molecular Medicine"},{"key":"b5-0330783","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.46.5.425"},{"key":"b6-0330783","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1980.tb00317.x"},{"key":"b7-0330783","doi-asserted-by":"publisher","DOI":"10.1159\/000163879"},{"key":"b8-0330783","doi-asserted-by":"publisher","DOI":"10.1007\/BF02389692"},{"key":"b9-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.01.012"},{"key":"b10-0330783","doi-asserted-by":"publisher","DOI":"10.1038\/ng1296-457"},{"key":"b11-0330783","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5338.680"},{"key":"b12-0330783","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14863"},{"key":"b13-0330783","first-page":"131","volume":"66","author":"Gabbiani G","year":"1972","journal-title":"American Journal of Pathology"},{"key":"b14-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.01.013"},{"key":"b15-0330783","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00699"},{"key":"b16-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(05)80067-X"},{"key":"b17-0330783","first-page":"443","volume":"2","author":"Kuhn MA","year":"2001","journal-title":"International Journal of Surgical Investigations"},{"key":"b18-0330783","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6350"},{"key":"b19-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(11)80184-4"},{"key":"b20-0330783","first-page":"203","volume":"143","author":"Margro G","year":"1997","journal-title":"General and Diagnostic Pathology"},{"key":"b21-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-968X(79)80045-5"},{"key":"b22-0330783","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.1036"},{"key":"b23-0330783","first-page":"275","volume-title":"The molecular and cellular biology of wound repair","author":"Roberts AB","year":"1995","edition":"2"},{"key":"b24-0330783","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(86)80143-5"},{"key":"b25-0330783","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198769090-00013"},{"key":"b26-0330783","first-page":"2912","volume":"8","author":"Tuxhorn JA","year":"2002","journal-title":"Clinical Cancer Research"},{"key":"b27-0330783","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000081462.40448.49"}],"container-title":["Journal of Hand Surgery (European Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193408091352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753193408091352","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193408091352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:42:49Z","timestamp":1777502569000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753193408091352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,20]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1177\/1753193408091352"],"URL":"https:\/\/doi.org\/10.1177\/1753193408091352","relation":{},"ISSN":["1753-1934","2043-6289"],"issn-type":[{"value":"1753-1934","type":"print"},{"value":"2043-6289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,20]]}}}