{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:56:28Z","timestamp":1780505788689,"version":"3.54.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T00:00:00Z","timestamp":1266969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Luck (1959) described a histological staging system for Dupuytren\u2019s disease, classifying the disease into three stages. Previous biochemical and immunochemical studies have detailed the decrease in type III\/I collagen ratio with disease progression. Herovici (1963) described a histological stain that produced a differential red\/purple and blue colour for type I and III collagen respectively. We stained 15 specimens of Dupuytren\u2019s disease and quantified the different collagen types in each using computer analysis. We found a corresponding decrease in the amount of type III collagen as a percentage of the total collagen with disease progression: stage I range 35\u201349% (mean 38%); stage 2 range 21\u201333% (mean 27%) and stage 3 range 11\u201319% (mean 14%). We propose a new staging system based on the relative amount of type III collagen, where stage 1: &gt;35%, stage 2: &gt;20% and &lt;35%, and stage 3: &lt;20%.<\/jats:p>","DOI":"10.1177\/1753193410362848","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T23:53:47Z","timestamp":1267055627000},"page":"312-317","source":"Crossref","is-referenced-by-count":45,"title":["Re-visiting Luck\u2019s classification: a histological                     analysis of Dupuytren\u2019s disease"],"prefix":"10.1177","volume":"35","author":[{"given":"W. L.","family":"Lam","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery and Burns Research Unit,\r                School of Biomedical Sciences, University of Bradford, Bradford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Rawlins","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Research Unit,\r                School of Biomedical Sciences, University of Bradford, Bradford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. O. S.","family":"Karoo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Research Unit,\r                School of Biomedical Sciences, University of Bradford, Bradford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Naylor","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Research Unit,\r                School of Biomedical Sciences, University of Bradford, Bradford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. T.","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burns Research Unit,\r                School of Biomedical Sciences, University of Bradford, Bradford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,2,24]]},"reference":[{"key":"bibr1-1753193409362848","first-page":"57","volume":"2","author":"Anderson W","year":"1891","journal-title":"Lecture 1 Part 2. 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