{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:13:52Z","timestamp":1793916832766,"version":"4.8.0"},"reference-count":67,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:00:00Z","timestamp":1389139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Extravasation injuries are common emergencies in clinical practice. If they are not recognized and treated promptly, they can lead to deleterious functional and cosmetic outcomes. There is a vast range of agents involved in these injuries and marked paucity of evidence to support their specific management. Following an extensive literature review, we outline management principles for clinicians involved in the care of patients with extravasation injuries. Key parameters in deciding appropriate management plans include the volume\/toxicity of the agent, the necrosis interval of the injury, patient-related factors, as well as the facilities and expertise available in the setting of individual cases of extravasation.<\/jats:p>","DOI":"10.1177\/1753193413511921","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:49:28Z","timestamp":1389228568000},"page":"808-818","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["Extravasation injuries: a review"],"prefix":"10.1177","volume":"39","author":[{"given":"I.","family":"Goutos","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Headington, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. K.","family":"Cogswell","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Headington, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Giele","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, John Radcliffe Hospital, Headington, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,8]]},"reference":[{"key":"bibr1-1753193413511921","first-page":"104","volume":"33","author":"Ayre\u2013Smith G","year":"1982","journal-title":"J Can Assoc Radiol"},{"key":"bibr2-1753193413511921","unstructured":"Baseportal database. http:\/\/baseportal.com\/cgibin\/baseportal.pl?htx=\/Isobel_Hawley\/main (accessed 03.03.2012)."},{"key":"bibr3-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1630-9"},{"key":"bibr4-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199608000-00012"},{"key":"bibr5-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1007\/BF01191807"},{"key":"bibr6-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.212.2.r99au14431"},{"key":"bibr7-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199005000-00006"},{"key":"bibr8-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.176.1.2353113"},{"key":"bibr9-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.200.3.8756899"},{"key":"bibr10-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/S1076-6332(97)80073-6"},{"key":"bibr11-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930220217"},{"key":"bibr12-1753193413511921","first-page":"2410","volume":"41","author":"Cox RF","year":"1984","journal-title":"Am J Hosp Pharm"},{"key":"bibr13-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1080\/02844310410027383"},{"key":"bibr14-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1136\/fn.70.1.F50"},{"key":"bibr15-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410379553"},{"key":"bibr16-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254235"},{"key":"bibr17-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960701)78:1<152::AID-CNCR21>3.0.CO;2-Y"},{"key":"bibr18-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh214"},{"key":"bibr19-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1080\/02844310601088221"},{"key":"bibr20-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.206.3.9494479"},{"key":"bibr21-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(93)90137-Z"},{"key":"bibr22-1753193413511921","first-page":"CD008404","volume":"2","author":"Gopalakrishnan PN","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr23-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(72)80087-4"},{"key":"bibr24-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303814"},{"key":"bibr25-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2011.10.001"},{"key":"bibr26-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.17.2.217"},{"key":"bibr27-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)31322-5"},{"key":"bibr28-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.209.2.9807567"},{"key":"bibr29-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2003.10.003"},{"key":"bibr30-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2007-0247"},{"key":"bibr31-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200206000-00011"},{"key":"bibr32-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.2001.02104.x"},{"key":"bibr33-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200210000-00006"},{"key":"bibr34-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820501)49:9<1796::AID-CNCR2820490911>3.0.CO;2-M"},{"key":"bibr35-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/S1548-5315(11)70111-5"},{"key":"bibr36-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198409000-00003"},{"key":"bibr37-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(83)80048-3"},{"key":"bibr38-1753193413511921","first-page":"401","volume":"70","author":"Loth TS","year":"1986","journal-title":"Cancer Treat Rep"},{"key":"bibr39-1753193413511921","first-page":"248","volume":"272","author":"Loth TS","year":"1991","journal-title":"Clin Orthop Relat Res"},{"key":"bibr40-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197904000-00003"},{"key":"bibr41-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.20.1556"},{"key":"bibr42-1753193413511921","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.160.1.8416624"},{"key":"bibr43-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl413"},{"key":"bibr44-1753193413511921","unstructured":"National Extravasation Information Centre. Extravasation risk factors \u2014 the drug or infusate, 2005. http:\/\/www.extravasation.org.uk\/druginfusate.htm (accessed 03.03.2012)."},{"key":"bibr45-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930230409"},{"key":"bibr46-1753193413511921","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.158.4.1546614"},{"key":"bibr47-1753193413511921","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.68.6.0967"},{"key":"bibr48-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198503000-00017"},{"key":"bibr49-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.7.1116"},{"key":"bibr50-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.06.002"},{"key":"bibr51-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.02.024"},{"key":"bibr52-1753193413511921","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2000.20.3.54"},{"key":"bibr53-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2007.05.003"},{"key":"bibr54-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1188\/09.CJON.395-398"},{"key":"bibr55-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2010.11.010"},{"key":"bibr56-1753193413511921","first-page":"479","volume":"19","author":"Shamseddine AI","year":"1998","journal-title":"Eur J Gynaecol Oncol"},{"key":"bibr57-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30355-7"},{"key":"bibr58-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.180.3.1871281"},{"key":"bibr59-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.04.040"},{"key":"bibr60-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1241185"},{"key":"bibr61-1753193413511921","unstructured":"Thames Valley Cancer Network (TVCN). Guidelines on treatment of extravasation injuries, 2006. http:\/\/www.tvcn.nhs.uk\/protocols\u2013guidelines\/clinical-guidelines\/extravasation\/ (accessed 24.10.2012)."},{"key":"bibr62-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1080\/02841850701324094"},{"key":"bibr63-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1990.tb00073.x"},{"key":"bibr64-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(79)90121-1"},{"key":"bibr65-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200001000-00019"},{"key":"bibr66-1753193413511921","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90035-H"},{"key":"bibr67-1753193413511921","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.162.6.8192049"}],"container-title":["Journal of Hand Surgery (European Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193413511921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753193413511921","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193413511921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:49:49Z","timestamp":1777502989000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753193413511921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,8]]},"references-count":67,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1177\/1753193413511921"],"URL":"https:\/\/doi.org\/10.1177\/1753193413511921","relation":{},"ISSN":["1753-1934","2043-6289"],"issn-type":[{"value":"1753-1934","type":"print"},{"value":"2043-6289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,8]]}}}