{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:22:24Z","timestamp":1780471344187,"version":"3.54.1"},"reference-count":18,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T00:00:00Z","timestamp":1387843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Raynaud\u2019s syndrome contributes to the pain, paraesthesia, ulceration, and gangrene of scleroderma. Botulinum toxin has been shown to improve digital perfusion in patients with Raynaud\u2019s. This is the first study to objectively assess hand function following this treatment in patients with scleroderma. Twenty patients were treated with 100 units of botulinum toxin injected into the hand. An assessment of hand function and symptoms was performed prior to injection and then 8\u201312 weeks later. The outcomes assessed were change in pain, appearance, cold intolerance, pinch and power grip, ranges of movement, and Disabilities of the Arm, Shoulder and Hand (DASH) score. In total, 80% of patients reported an overall improvement in their symptoms, reduction in pain, and improved DASH score and 65% reported improvement in cold intolerance. Overall, 90% showed an improvement in pinch grip and 65% an improvement in power grip. Objective parameters were statistically significantly improved; however, subjective outcomes only showed a trend. We have found botulinum toxin to be an effective treatment for Raynaud\u2019s syndrome secondary to scleroderma.<\/jats:p>","DOI":"10.1177\/1753193413516242","type":"journal-article","created":{"date-parts":[[2013,12,25]],"date-time":"2013-12-25T20:19:38Z","timestamp":1388002778000},"page":"876-880","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":71,"title":["A prospective study of the use of botulinum toxin injections in the treatment of Raynaud\u2019s syndrome associated with scleroderma"],"prefix":"10.1177","volume":"39","author":[{"given":"L.","family":"Uppal","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Free Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Free Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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