{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:03:21Z","timestamp":1777853001896,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,1,26]],"date-time":"2014-01-26T00:00:00Z","timestamp":1390694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>In POINT X, a study designed to reflect clinical practice and patient treatment choices, 254 European patients received open-label collagenase for Dupuytren\u2019s contracture. The most severely affected joint was treated first in 74% of patients. In total, 52%, 41%, 7%, and 1% of patients selected the little, ring, middle, and index finger, respectively; 79% had one or two joints treated. Only 9% of patients ( n = 24) received 4 or 5 injections. The mean improvement in total passive extension deficit (TPED) was 34\u00b0 on day 1, improving further by day 7 to 42\u00b0. This secondary improvement was maintained by day 90 and month 6. The mean number of injections\/joint was 1.2 for the metacarpophalangeal joint and 1.25 for the proximal interphalangeal joint. Median time to recovery was 4 days; the mean improvement in hand function was clinically relevant as measured by the Unit\u00e9 Rhumatologique des Affections de la Main (URAM) score. In total, 87% and 86% of patients and physicians, respectively, were very satisfied or satisfied with treatment at month 6, although correlation between TPED and patient satisfaction was weak (Spearman \u22120.18, 95% CI \u22120.32 to \u22120.06). Collagenase was well tolerated, with 10 (3.9%) patients experiencing severe adverse events. As a real-world study, the POINT X findings can be generalized to the at-large population.<\/jats:p>","DOI":"10.1177\/1753193413519926","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T21:05:54Z","timestamp":1390856754000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Collagenase\n                    <i>clostridium histolyticum<\/i>\n                    in patients with Dupuytren\u2019s contracture: results from POINT X, an open-label study of clinical and patient-reported outcomes"],"prefix":"10.1177","volume":"40","author":[{"given":"D.","family":"Warwick","sequence":"first","affiliation":[{"name":"National Institute of Health Research Wellcome Trust Clinical Research Facility, University Hospital Southampton, NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Arner","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery S\u00f6dersjukhuset and Department of Clinical Science & Education, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pajardi","sequence":"additional","affiliation":[{"name":"San Giuseppe MultiMedica University Hospital and Universit\u00e0 degli Studi di Milano, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Reichert","sequence":"additional","affiliation":[{"name":"Department for Plastic, Reconstructive & Hand Surgery, Nuremberg Hospital, Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Szabo","sequence":"additional","affiliation":[{"name":"Traumatology & Hand Surgery Department, BAZ University County Teaching Hospital, Miskolc, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. H.","family":"Masmejean","sequence":"additional","affiliation":[{"name":"Hand Surgery Unit, Georges-Pompidou European Hospital (HEGP), Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Paris-Descartes University, Sorbonne Paris Cit\u00e9, Paris Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fores","sequence":"additional","affiliation":[{"name":"Traumatolog\u00eda y Cirug\u00eda Ortop\u00e9dica, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Specialty Care Biostatistics, Pfizer Inc, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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P.","family":"Szczypa","sequence":"additional","affiliation":[{"name":"Medical Affairs, Pfizer Ltd, Tadworth Surrey, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the POINT X Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,26]]},"reference":[{"key":"bibr1-1753193413519926","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2007.04.002"},{"key":"bibr2-1753193413519926","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20564"},{"key":"bibr3-1753193413519926","unstructured":"Council for International Organizations of Medical Sciences, World Health Organization. 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Nonoperative treatment of PIPJ flexion contractures associated with Dupuytren\u2019s disease J Hand Surg Eur. 2012, 37, 722\u20137.","DOI":"10.1177\/1753193411422680"},{"key":"bibr9-1753193413519926","author":"Manning CJ","year":"2013","journal-title":"J Hand Surg Eur"},{"key":"bibr10-1753193413519926","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-012-9407-3"},{"key":"bibr11-1753193413519926","unstructured":"Pess G, Peimer C, Skodny P, Tursi J, Szczypa P, Gerber R. Efficacy and effectiveness of collagenase\n                      Clostridium histolyticum\n                      for Dupuytren\u2019s contracture: comparison of real-world data with clinical trial results. Presented at: XVII Congress of the Federation of European Societies for Surgery of the Hand; 29 May\u20131 June 2012; Antalya, Turkey."},{"key":"bibr12-1753193413519926","doi-asserted-by":"publisher","DOI":"10.1177\/1753193411407245"},{"key":"bibr13-1753193413519926","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aea95"},{"key":"bibr14-1753193413519926","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256918"},{"key":"bibr15-1753193413519926","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2012.10.008"},{"key":"bibr16-1753193413519926","unstructured":"World Medical Association. 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