{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:12:33Z","timestamp":1788567153195,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Safety was evaluated for collagenase Clostridium histolyticum (CCH) based on 11 clinical trials ( N = 1082) and compared with fasciectomy data in a structured literature review of 48 European studies ( N = 7727) for treatment of Dupuytren\u2019s contracture. Incidence of adverse events was numerically lower with CCH vs. equivalent complications from fasciectomy (median [range] incidence), including nerve injury (0% vs. 3.8% [0%\u221250+%]), neurapraxia (4.4% vs. 9.4% [0%\u221251.3%]), complex regional pain syndrome (0.1% vs. 4.5% [1.3%\u221218.5%]) and arterial injury (0% vs. 5.5% [0.8%\u221216.5%]). Tendon injury (0.3% vs. 0.1% [0%\u22120.2%]), skin injury (16.2% vs. 2.8% [0%\u221225.9%]) and haematoma (77.7% vs. 2.0% [0%\u221225%]) occurred at a numerically higher incidence with CCH than surgery. Adverse events in CCH trials not reported after fasciectomy included peripheral oedema; extremity pain; injection site pain, haemorrhage and swelling; tenderness; pruritus and lymphadenopathy. CCH-related adverse events were reported as predominantly injection-related and transient. These results may support clinical decision-making for treatment of Dupuytren\u2019s contracture.<\/jats:p>","DOI":"10.1177\/1753193414528843","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T20:39:38Z","timestamp":1396557578000},"page":"141-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":93,"title":["Safety and tolerability of collagenase Clostridium histolyticum and fasciectomy for Dupuytren\u2019s contracture"],"prefix":"10.1177","volume":"40","author":[{"given":"C. A.","family":"Peimer","sequence":"first","affiliation":[{"name":"College of Human Medicine, Michigan State University, Marquette, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wilbrand","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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