{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:39:06Z","timestamp":1780598346786,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Although Dupuytren\u2019s contracture is characterized by increased transforming growth factor-\u03b21 (TGF-\u03b21) and fibrosis in the palmar fascia, the relationship between TGF-\u03b21 and integrins, which are considered to be related to fibrosis, remains unclear. We investigated the involvement of TGF-\u03b21 and integrins in the pathological palmar fascia of Dupuytren\u2019s contracture. Seven patients underwent partial fasciectomy for treatment of this disease. The nodule and cord were isolated from the fascial tissues of the patients. Control fasciae were obtained from seven patients with carpal tunnel syndrome. Immunohistochemical analysis was performed to detect the fibrosis marker \u03b1-smooth muscle actin and integrins in the fascial tissues. The expression of TGF-\u03b21 and integrins was assessed by real-time polymerase chain reaction. The results suggest that nodules may be areas involved in activation of fibrosis in the fascia, associated with increased expression of TGF-\u03b21 and \u03b1v integrin. Thus, \u03b1v integrin may contribute to fibrosis in Dupuytren\u2019s contracture by activating TGF-\u03b21.<\/jats:p>\n                  <jats:p>Level of Evidence: IV<\/jats:p>","DOI":"10.1177\/1753193416635489","type":"journal-article","created":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T21:03:40Z","timestamp":1457730220000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased expression of \u03b1v integrin as a regulator of fibrosis in Dupuytren\u2019s nodules"],"prefix":"10.1177","volume":"42","author":[{"given":"Y.","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kon","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Pharmaceutical Sciences, 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