{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:12:36Z","timestamp":1788567156521,"version":"build-2803163510"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>To assess the efficacy, safety and pharmacokinetics of 0.58\u2009mg collagenase Clostridium histolyticum injections for the treatment of Dupuytren\u2019s contracture in Japanese patients, we conducted a phase III, multicentre, uncontrolled, open-label clinical study in patients with Dupuytren\u2019s contracture. Of the 77 patients, 66 achieved clinical success in the primary treated joint (86%; 95% confidence interval: 76% to 93%), confirming the efficacy of collagenase Clostridium histolyticum injections. More improvement was seen in the metacarpophalangeal joints than in the proximal interphalangeal joints (94% versus 73%). The main adverse reaction was a local reaction in the injected hand. No tendon rupture or anaphylactic reactions were seen. The concentrations of collagenase Clostridium histolyticum were below the lower limit of quantification in plasma samples at all time points. As seen in global studies in Caucasian patients, a corrective effect on Dupuytren\u2019s contracture and good tolerance were observed in most non-Caucasian (Asian) Japanese patients.<\/jats:p>\n                  <jats:p>Level of Evidence: Level 3<\/jats:p>","DOI":"10.1177\/1753193416653249","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T21:24:20Z","timestamp":1466112260000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of collagenase\n                    <i>Clostridium histolyticum<\/i>\n                    injection for Dupuytren\u2019s contracture in non-Caucasian Japanese patients (CORD-J Study): the first clinical trial in a non-Caucasian population"],"prefix":"10.1177","volume":"42","author":[{"given":"H.","family":"Hirata","sequence":"first","affiliation":[{"name":"Department of Hand Surgery, Graduate School of Nagoya University, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Nagasaki University, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kakinoki","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Kyoto University Hospital, Kyoto, Japan"},{"name":"Current address: Department of Orthopaedic Surgery, Kindai University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ikegami","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Toho University Ohashi Medical Center, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Development Planning, Clinical Development Center, Asahi Kasei Pharma Corporation, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"bibr1-1753193416653249","first-page":"6921","volume":"60","author":"Ando Y","year":"2000","journal-title":"Cancer Res"},{"key":"bibr2-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1980.tb00003.x"},{"key":"bibr3-1753193416653249","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163050-00014"},{"key":"bibr4-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1177\/1753193410397971"},{"key":"bibr5-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2011.02.016"},{"key":"bibr6-1753193416653249","first-page":"100","volume-title":"Dupuytren\u2019s disease","author":"Egawa T","year":"1985"},{"key":"bibr7-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1021\/bi00377a004"},{"key":"bibr8-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb06234.x"},{"key":"bibr9-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.08.007"},{"key":"bibr10-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00145-6"},{"key":"bibr11-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.142.437"},{"key":"bibr12-1753193416653249","first-page":"141","volume-title":"Green\u2019s operative hand surgery","author":"Hurst LC","year":"2010","edition":"6"},{"key":"bibr13-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"bibr14-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1994.tb01768.x"},{"key":"bibr15-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.39.3.255"},{"key":"bibr16-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2011.00614.x"},{"key":"bibr17-1753193416653249","first-page":"201","volume-title":"Dupuytren\u2019s disease biology and treatment","author":"McFarlane RM","year":"1990"},{"key":"bibr18-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328014341f"},{"key":"bibr19-1753193416653249","first-page":"116","volume":"1","author":"Mookhtiar KA","year":"1992","journal-title":"Matrix Suppl"},{"key":"bibr20-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2013.08.114"},{"key":"bibr21-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1177\/1753193414528843"},{"key":"bibr22-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1084\/jem.143.6.1299"},{"key":"bibr23-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-199907000-00003"},{"key":"bibr24-1753193416653249","first-page":"17","volume":"23","author":"Rydevik B","year":"1989","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"bibr25-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2014.34"},{"key":"bibr26-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31271-1"},{"key":"bibr27-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-013-0478-y"},{"key":"bibr28-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1177\/1753193414530590"},{"key":"bibr29-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1177\/1753193415600670"},{"key":"bibr30-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1155\/MI.2005.31"},{"key":"bibr31-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1042\/bj1390359"},{"key":"bibr32-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2012.06.032"},{"key":"bibr33-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2012.10.008"},{"key":"bibr34-1753193416653249","unstructured":"Xiaflex (collagenase\n                      Clostridium histolyticum\n                      ) [package insert]. Malvern, AR: Auxilium Pharmaceuticals, Inc.; 2010."},{"key":"bibr35-1753193416653249","unstructured":"Xiapex 0.9\u2009mg powder and solvent for solution for injection [package insert]. Kent, UK, Pfizer Ltd; 2011."},{"key":"bibr36-1753193416653249","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-013-2195-9"}],"container-title":["Journal of Hand Surgery (European Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193416653249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753193416653249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193416653249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:47:36Z","timestamp":1777502856000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753193416653249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/1753193416653249"],"URL":"https:\/\/doi.org\/10.1177\/1753193416653249","relation":{},"ISSN":["1753-1934","2043-6289"],"issn-type":[{"value":"1753-1934","type":"print"},{"value":"2043-6289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}