{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:43:50Z","timestamp":1790419430251,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Thalidomide embryopathy results from the ingestion of thalidomide in the first trimester during pregnancy, causing multiple forms of congenital abnormalities of variable severity that involve all systems. The skeletal findings most frequently affect the limbs, particularly the upper limbs and hands. Increasingly, several genetic disorders with similar birth defects have been identified. New cases of malformations owing to possible exposure to thalidomide continue to present through both historical and current usage. However, inadequate proof of ingestion, marked phenotypic variation and the possibility of an alternative genetic condition, hinder the diagnosis of thalidomide embryopathy. We introduce a \u2018diagnostic algorithm for thalidomide embryopathy\u2019 (DATE) diagnostic software that can potentially provide a numerical score for the likelihood of birth defects in an individual as being caused by exposure to thalidomide and to provide a differential diagnosis based on the pattern of malformation.<\/jats:p>","DOI":"10.1177\/1753193418800631","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T02:23:50Z","timestamp":1537928630000},"page":"96-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["A clinical review and introduction of the diagnostic algorithm for thalidomide embryopathy (DATE)"],"prefix":"10.1177","volume":"44","author":[{"given":"Sahar","family":"Mansour","sequence":"first","affiliation":[{"name":"Molecular and Clinical Sciences Institute, St George\u2019s University of London, London, UK"},{"name":"SW Thames Regional Genetics Service, St George\u2019s Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Baple","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Sciences Institute, St George\u2019s University of London, London, UK"},{"name":"Medical Research, University of Exeter Medical School, Exeter, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M","family":"Hall","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Sciences Institute, St George\u2019s University of London, London, UK"},{"name":"Emeritus of Department of Radiology, Great Ormond Street Children\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"bibr1-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(97)00174-7"},{"key":"bibr2-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199612)54:6<273::AID-TERA1>3.0.CO;2-#"},{"key":"bibr3-1753193418800631","unstructured":"Kida M (Ed.)\n                      Thalidomide embryopathy in Japan\n                      . Tokyo, Kodansha, 1987."},{"key":"bibr4-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.7.473"},{"key":"bibr5-1753193418800631","first-page":"33","volume":"176","author":"Kreipe U","year":"1967","journal-title":"Arch Kinderheilkd"},{"key":"bibr6-1753193418800631","first-page":"2555","volume":"52","author":"Lenz W","year":"1961","journal-title":"Dtsch Med Wochenschr"},{"key":"bibr7-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1111892"},{"key":"bibr8-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)90927-8"},{"key":"bibr9-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6944.1635b"},{"key":"bibr10-1753193418800631","first-page":"100","volume":"106","author":"Miller MT","year":"2008","journal-title":"Trans Am Ophthalmol Soc"},{"key":"bibr11-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199911)60:5<306::AID-TERA11>3.0.CO;2-Y"},{"key":"bibr12-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e3283499f24"},{"key":"bibr14-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1007\/BF00338341"},{"key":"bibr15-1753193418800631","unstructured":"Reports on Public Health and Medical Subjects. No.112\n                      Deformities caused by thalidomide.\n                      London: HMSO, 1964."},{"key":"bibr16-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20384"},{"key":"bibr17-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)92129-9"},{"key":"bibr18-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.10.716"},{"key":"bibr19-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1993.tb04997.x"},{"key":"bibr20-1753193418800631","unstructured":"Tanaka Y. Otolaryngology in thalidomide embryopathy. In: Kida M, (ed.)\n                      Thalidomide embryopathy in Japan\n                      . Tokyo, Kodansha, 1987: 155\u20139."},{"key":"bibr21-1753193418800631","unstructured":"UK Teratology Information Service, 2015. http:\/\/www.medicinesinpregnancy.org\/bumps\/monographs\/USE-OF-THALIDOMIDE-LENALIDOMIDE-AND-POMALIDOMIDE-IN-PREGNANCY\/ (accessed 17 April 2018)."},{"key":"bibr22-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442335"},{"key":"bibr123-1753193418800631","doi-asserted-by":"crossref","unstructured":"Vargesson N. The teratogenic effects of thalidomide on limbs.\n                      J Hand Surg Eur\n                      . 2018 (in press).","DOI":"10.1177\/1753193418805249"},{"key":"bibr23-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21096"},{"key":"bibr24-1753193418800631","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021735"},{"key":"bibr25-1753193418800631","first-page":"1863","volume":"37","author":"Wiedemann HR","year":"1961","journal-title":"Med Welt"}],"container-title":["Journal of Hand Surgery (European Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193418800631","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753193418800631","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193418800631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:48:57Z","timestamp":1777502937000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753193418800631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,25]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1177\/1753193418800631"],"URL":"https:\/\/doi.org\/10.1177\/1753193418800631","relation":{},"ISSN":["1753-1934","2043-6289"],"issn-type":[{"value":"1753-1934","type":"print"},{"value":"2043-6289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,25]]}}}