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The findings of triphalangeal thumb can be predictive for other congenital anomalies as part of an underlying syndrome. Furthermore, triphalangeal thumb is still being used as a model in molecular genetics to study gene regulation by long-range regulatory elements. We present a review that summarizes a number of scientifically relevant topics that involve the triphalangeal thumb phenotype. Future initiatives involving multidisciplinary teams collaborating in the field of triphalangeal thumb research can lead to a better understanding of the pathogenesis and molecular mechanisms of this condition as well as other congenital upper limb anomalies.<\/jats:p>","DOI":"10.1177\/1753193418803521","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T02:26:23Z","timestamp":1539570383000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["A multidisciplinary review of triphalangeal thumb"],"prefix":"10.1177","volume":"44","author":[{"given":"Jacob W. 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