{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:03:11Z","timestamp":1791291791232,"version":"4.1.0"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>It has been suggested that Dupuytren\u2019s disease has an origin in Norse countries. We harnessed data from a genome-wide association study of Dupuytren\u2019s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren\u2019s disease. We computed Wright\u2019s Fixation Index between Orkney (Norse ancestry), Wales (ancient British) and South East England (Anglo-Saxons); compared mean Wright\u2019s Fixation Index in cases versus controls; used permutation to determine any excess of Norse inheritance in disease associated variants; constructed a genetic risk score for Dupuytren\u2019s disease and applied this to the People of the British Isles dataset to look for systematic differences between counties with known high and low levels of Norse ancestry. Finally, chromosome painting was used to see whether Dupuytren\u2019s disease-associated single nucleotide polymorphisms are geographically structured. In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren\u2019s disease. We conclude that there is no genetic evidence for a \u2018Viking origin of Dupuytren\u2019s disease\u2019.<\/jats:p>","DOI":"10.1177\/1753193419882851","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T09:17:08Z","timestamp":1572427028000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Is Dupuytren\u2019s disease really a \u2018disease of the Vikings\u2019?"],"prefix":"10.1177","volume":"45","author":[{"given":"Michael","family":"Ng","sequence":"first","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Lawson","sequence":"additional","affiliation":[{"name":"Integrative Epidemiology Unit, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Winney","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Furniss","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Oxford, UK"},{"name":"NIHR Biomedical Research Centre, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"bibr1-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2014.10.011"},{"key":"bibr2-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/46.1.71"},{"key":"bibr3-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101029"},{"key":"bibr4-1753193419882851","unstructured":"Egawa T, Senuri S, Horiki A, Egawa M. Epidemiology of the Oriental patient. In: Mcfarlane RM MD, Flint MH (Eds)\n                      Dupuytren\u2019s disease.\n                      Edinburgh, Churchill Livingstone, 1990: 239\u201345."},{"key":"bibr5-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681_88_90078-2"},{"key":"bibr6-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2001.11927791"},{"key":"bibr7-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.69"},{"key":"bibr8-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1177\/1753193416640465"},{"key":"bibr9-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-9053(88)80013-9"},{"key":"bibr10-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.027425"},{"key":"bibr11-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-008-9160-9"},{"key":"bibr12-1753193419882851","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/genetics\/132.2.583","volume":"132","author":"Hudson RR","year":"1992","journal-title":"Genetics"},{"key":"bibr13-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002453"},{"key":"bibr14-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1038\/nature14230"},{"key":"bibr15-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.08.006"},{"key":"bibr16-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005208"},{"key":"bibr17-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.101"},{"key":"bibr18-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7538.397"},{"key":"bibr19-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(93)90065-N"},{"key":"bibr20-1753193419882851","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2011.127"}],"container-title":["Journal of Hand Surgery (European Volume)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193419882851","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753193419882851","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753193419882851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:49:39Z","timestamp":1777502979000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753193419882851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1177\/1753193419882851"],"URL":"https:\/\/doi.org\/10.1177\/1753193419882851","relation":{},"ISSN":["1753-1934","2043-6289"],"issn-type":[{"value":"1753-1934","type":"print"},{"value":"2043-6289","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,30]]}}}