{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:06:50Z","timestamp":1777853210800,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Timing of manipulation of digits after collagenase injection for Dupuytren\u2019s disease varies and often takes place within the first few days post-injection. We prospectively investigated the effectiveness of performing manipulation under local anaesthesia 7 days after injection in 100 patients. Demographic data, passive extension deficit, and patient-reported outcome measures were recorded before collagenase injection. Four to 7 weeks after manipulation, passive extension deficit and patient-reported outcome measures improved significantly without the development of any tendon ruptures. Clinical success was achieved in 41% and clinical improvement in 76% of the patients. Adverse events were reported by 85%. The outcomes were comparable with studies with early manipulation, and demonstrate a safe and effective variation to current protocols. We conclude that delaying manipulation to 7 days after collagenase injection is safe and efficient, which allows for flexibility in clinical appointments without negatively affecting outcome.<\/jats:p>\n                  <jats:p>Level of evidence: III<\/jats:p>","DOI":"10.1177\/1753193419890770","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T03:19:05Z","timestamp":1575947945000},"page":"286-291","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The effectiveness of manipulation of fingers with Dupuytren's contracture 7 days after collagenase clostridial histolyticum injection"],"prefix":"10.1177","volume":"45","author":[{"given":"Bethany","family":"Reynolds","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Peninsula Health, Frankston, Australia"},{"name":"Peninsula Clinical School, Central Clinical School at Monash University, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Peninsula Health, Frankston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian A","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgery, Monash Medical Centre, Clayton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren M","family":"Rozen","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, Peninsula Health, Frankston, Australia"},{"name":"Peninsula Clinical School, Central Clinical School at Monash University, Melbourne, Australia"},{"name":"Department of Surgery, Monash Medical Centre, Clayton, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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