{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:22:54Z","timestamp":1787242974018,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:p>\n                    We performed Mendelian randomization analyses of body mass index and waist\u2013hip ratio adjusted for body mass index in Dupuytren\u2019s disease using summary statistics from genome-wide association study meta-analyses. We found that adiposity is causally protective against Dupuytren\u2019s disease, with the inverse-variance weighted Mendelian randomization analysis estimating that a 1 standard deviation increase in body mass index (equivalent to 4.8\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) leads to 28% (95% confidence interval: 18\u201337%) lower relative odds of developing Dupuytren\u2019s disease, and a 1 standard deviation increase in waist\u2013hip ratio adjusted for body mass index (equivalent to a waist\u2013hip ratio of 0.09) leads to 26% (95% confidence interval: 6\u201342%) lower relative odds of developing Dupuytren\u2019s disease. We conclude from this study that regardless of the well-established negative health effects of obesity, the raised body mass index is associated with a lower risk of Dupuytren\u2019s disease and may be causally protective for the development of the disease.\n                  <\/jats:p>","DOI":"10.1177\/1753193420958553","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T03:39:25Z","timestamp":1601005165000},"page":"406-410","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["The relationship between body mass index and the risk of development of Dupuytren\u2019s disease: a Mendelian randomization study"],"prefix":"10.1177","volume":"46","author":[{"given":"Mustafa","family":"Majeed","sequence":"first","affiliation":[{"name":"Medical Sciences Division, University of Oxford, Oxford, 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