{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:02:46Z","timestamp":1777852966596,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>The aim of this study was to report hand function, disability and satisfaction and patients\u2019 perception of functionally troublesome contractures 5 years after injection with collagenase Clostridium histolyticum and hand therapy for Dupuytren's disease. Data from 79 patients were collected before and at 3, 12 and 60 months after treatment. Hand function was significantly improved, and 70% achieved a functional range of motion in the treated hand. QuickDASH scores and range of motion were best at 3 months follow-up. At 60 months, mean total extension deficit was 48\u00b0, which was 57% of the deficit before treatment. Thirty-seven patients (47%) had developed recurrent contractures in treated finger(s) meeting the criteria for new treatment. The threshold for functionally troublesome contractures was found to be 30\u00b0\u201360\u00b0 in the finger joints. Treatment was experienced as painful, but few hand function problems occurred. Most patients would choose this treatment method again.<\/jats:p>\n                  <jats:p>Level of evidence: IV<\/jats:p>","DOI":"10.1177\/17531934211002383","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T01:54:21Z","timestamp":1616723661000},"page":"985-994","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Hand function 5 years after treatment with collagenase\n                    <i>Clostridium histolyticum<\/i>\n                    injection for Dupuytren\u2019s disease"],"prefix":"10.1177","volume":"46","author":[{"given":"Ingrid","family":"G\u00f6ransson","sequence":"first","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy, Kalmar County Hospital, Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Brudin","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Regional Council in Kalmar County, Kalmar, Sweden"},{"name":"Department of Health, Medicine and Caring Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andra","family":"Irbe","sequence":"additional","affiliation":[{"name":"Orthopaedic Clinic, Kalmar County Hospital, Kalmar, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Turesson","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Plastic Surgery and Burns, and Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"bibr1-17531934211002383","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7098.1874"},{"key":"bibr2-17531934211002383","doi-asserted-by":"publisher","DOI":"10.1080\/000164700317362262"},{"key":"bibr3-17531934211002383","doi-asserted-by":"publisher","DOI":"10.1177\/1753193414533754"},{"key":"bibr4-17531934211002383","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-131"},{"key":"bibr5-17531934211002383","doi-asserted-by":"crossref","unstructured":"Bell Krotoski J. Sensibility testing. In: Skirven T, Osterman L, Fedorczyk J, Amadio P (Eds.)\n                      Rehabilitation of the hand and upper extremity\n                      , 6th edn. Philadelphia: Elsevier\/Mosby, 2011, 1: 132\u201351.","DOI":"10.1016\/B978-0-323-05602-1.00011-8"},{"key":"bibr6-17531934211002383","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2016.03.003"},{"key":"bibr7-17531934211002383","first-page":"41","volume":"88","author":"Bryant D","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"bibr8-17531934211002383","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2014.4893"},{"key":"bibr9-17531934211002383","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2015.06.099"},{"key":"bibr10-17531934211002383","unstructured":"HAKIR. HQ-8-english questionnaire postoperative (2018). 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