{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:03:02Z","timestamp":1777852982146,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Hand Surg Eur Vol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>This study aimed to determine the association between the echogenicity of Dupuytren\u2019s disease nodules and myofibroblast load, and between echogenicity and nodule hardness. Thirty-eight nodules were assessed sonographically. The echogenicity of nodules was measured objectively with Image J (grey-value) and subjectively by visual inspection (hypo-, mixed and hyper-echogenicity). These findings were compared with myofibroblast load measured by histopathological analysis. In a different cohort, 97 nodules were assessed for grey-value and nodule hardness using a tonometer. There was a moderate, significant, negative association between grey-value and myofibroblast load and the subjective visual measurements corresponded to this finding. There was also a moderate, significant, negative association between grey-value and nodule hardness. Ultrasound and tonometry may be useful in the selection of patients for possible future preventive treatments.<\/jats:p>","DOI":"10.1177\/17531934211050214","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T11:04:12Z","timestamp":1633604652000},"page":"280-287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Echogenicity of Dupuytren\u2019s nodules is correlated to myofibroblast load and nodule hardness"],"prefix":"10.1177","volume":"47","author":[{"given":"Sanne","family":"Molenkamp","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whangzao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein","family":"Bloembergen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieuwke C.","family":"Broekstra","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, University of Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M. 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