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The cC7 was initially postulated to restore function by replacing injured nerves at the peripheral level, but dynamic cortical reorganization has since been demonstrated post-surgery, which potentially allows harnessing of the cC7 procedure to expand the span of control of the uninjured hemisphere in conditions like hemiplegic stroke. By integrating principles of nerve regeneration and brain plasticity through phased rehabilitation programmes, published clinical results have demonstrated significant improvements in upper limb function, confirming the procedure\u2019s safety and efficacy, with donor site morbidity that is typically mild and transient. The cC7 procedure may play a major role in the future of restoring upper limb function in patients who have suffered upper motor neurone lesions.<\/jats:p>","DOI":"10.1177\/17531934251314640","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T05:05:08Z","timestamp":1738904708000},"page":"796-806","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Harnessing the uninjured hemisphere for treatment of the stroke or brain-injured patient \u2013 evolution of the contralateral C7 transfer"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3085-5806","authenticated-orcid":false,"given":"Wendong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Hand Surgery, Jing\u2019an District Central Hospital, Branch of Huashan Hospital, the National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China"},{"name":"Institute of Brain Science, State Key Laboratory of Medical Neurobiology and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China"},{"name":"National Clinical Key Specialty for Limb Function Reconstruction, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM187210170871601"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2064"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/17531934231170103"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101258"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.16436"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-022-00959-x"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn5899"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"e_1_3_5_10_1","volume-title":"Diagnosis and Treatment of Brachial Plexus Injury and Disease","author":"Gu YD.","year":"1992","unstructured":"Gu YD. 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