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Sixty patients were randomized to observation or radiotherapy (30\u2009Gy, 10 fractions) starting within 4 days of the procedure. During a follow-up period of up to 4 years, 114 adverse events were reported. Of 102 (89%) mild adverse events, 45 (44.1%) were attributed to radiotherapy. Of the 12 moderate to severe, three were attributed to radiotherapy. By 6 months, most moderate to severe adverse events had resolved. Between 12 and 36 month follow-ups, the only persistent adverse event attributed to radiotherapy was reduced sweating. In this trial of adjuvant radiotherapy for Dupuytren\u2019s disease, adverse events are generally mild and self-limiting, suggesting that adjuvant radiotherapy is well tolerated.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Level of evidence:<\/jats:bold>\n                    Level 2, individual RCT\n                  <\/jats:p>","DOI":"10.1177\/17531934251321393","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T03:20:34Z","timestamp":1740712834000},"page":"891-897","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Adverse events after adjuvant radiation therapy for Dupuytren\u2019s disease in the DEPART randomized trial"],"prefix":"10.1177","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3187-3713","authenticated-orcid":false,"given":"Tanya","family":"Burgess","sequence":"first","affiliation":[{"name":"Newcastle Hand Institute, Newcastle, Australia"},{"name":"Hunter Hand Surgery, Newcastle, Australia"},{"name":"University of Newcastle, Newcastle, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wegener","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, Australia"},{"name":"GenesisCare Lake Macquarie Private Hospital, Lake Macquarie, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"McClelland","sequence":"additional","affiliation":[{"name":"Newcastle Hand Institute, Newcastle, Australia"},{"name":"Hunter Hand Surgery, Newcastle, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hunter-Smith","sequence":"additional","affiliation":[{"name":"Newcastle Hand Institute, Newcastle, Australia"},{"name":"Peninsula Clinical School, Central Clinical School at Monash University, The Alfred Centre, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.N.","family":"Werker","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen, Department of Plastic Surgery, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarad","family":"Martin","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, Australia"},{"name":"GenesisCare Lake Macquarie Private Hospital, Lake Macquarie, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DEPART Clinical Trial Collaboration","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00002371"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.23025"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-010-2063-z"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009115"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm1814119"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-021-01801-5"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1394420"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193417695996"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00421-X"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsg.2023.06.017"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.05.022"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.11.015"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aea95"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-015-0818-2"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753193416641590"},{"key":"e_1_3_5_17_1","unstructured":"The Royal College of Radiologists. 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