{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:50:47Z","timestamp":1788573047233,"version":"build-2803163510"},"reference-count":51,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>Objective: Seropositivity for Chlamydia pneumoniae has been associated with an elevated body mass index (BMI). Our aim was to study if serum chlamydial lipopolysaccharide (cLPS), C. pneumoniae antibodies and high-sensitivity C-reactive protein (hsCRP) levels are associated with BMI<\/jats:p>\n                  <jats:p>Patients and Methods : The study population consisted of 174 patients with symptomatic carotid stenosis, abdominal aortic aneurysm or occlusive aortic disease. Information on BMI, diabetes, smoking, hypercholesterolemia, and statin medication was available. Serum C. pneumoniae IgG and IgA antibodies, cLPS, hsCRP and total endotoxin activity (totLPS) were measured.<\/jats:p>\n                  <jats:p>\n                    Results: BMI correlated with cLPS ( r = 0.197; P &lt; 0.01) and with hsCRP (\u03c1 = 0.195; P &lt; 0.01); in addition, there was a positive correlation between cLPS and hsCRP (\u03c1 = 0.499; P &lt; 0.01). A trend of an increasing proportion of C. pneumoniae IgG positivity (titre \u2265 64; P = 0.018) and higher serum cLPS ( P = 0.01) and hsCRP ( P = 0.01) concentrations was observed across the BMI groups (BMI \u2264 24.9 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , BMI = 25.0\u201429.9 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , and BMI \u2265 30.0 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ). Among the three BMI groups, 24.6%, 38.8%, and 48.3% were C. pneumoniae IgG-positive and the median (IQR) cLPS concentrations (ng\/ml) of the groups were: 92.6 (50.8\u2014167.0), 128.9 (76.4\u2014163.9), and 146.4 (105.8\u2014175.8), respectively. The median (IQR) hsCRP (mg\/l) concentrations of the groups were: 1.70 (0.70\u20143.05) 1.70 (0.80\u20145.20), and 3.40 (1.45\u20148.55), respectively. These associations remained statistically significant in a multivariate analysis.\n                  <\/jats:p>\n                  <jats:p>Conclusions: Elevated serum cLPS levels were associated with an elevated BMI. This is a novel finding and it strengthens the link between chlamydial infection and obesity. A lack of association between totLPS and BMI suggests that the association between infection and an elevated BMI may be specific to certain pathogens.<\/jats:p>","DOI":"10.1177\/1753425908099172","type":"journal-article","created":{"date-parts":[[2008,11,27]],"date-time":"2008-11-27T09:33:54Z","timestamp":1227778434000},"page":"375-382","source":"Crossref","is-referenced-by-count":20,"title":["Chlamydial LPS and high-sensitivity CRP levels in serum are associated with an elevated body mass index in patients with cardiovascular disease"],"prefix":"10.1177","volume":"14","author":[{"given":"Taina","family":"Lajunen","sequence":"first","affiliation":[{"name":"Respiratory Infection Unit, National Public Health Institute, Oulu, Finland, , Department of Medical Microbiology, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkka","family":"Vikatmaa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aini","family":"Bloigu","sequence":"additional","affiliation":[{"name":"Respiratory Infection Unit, National Public Health Institute, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuija","family":"Ikonen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland, Department of Surgery, Turku University Central Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauri","family":"Lep\u00e4ntalo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular Surgery, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkko 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