{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:45:26Z","timestamp":1791031526243,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T00:00:00Z","timestamp":1281052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p>\n                    Arsenic trioxide, As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    , already used in human anti-cancer therapy, is also an efficient agent against the autoimmune and inflammatory diseases developed in MRL\/lpr mice. Inflammatory bowel diseases (IBDs), notably Crohn\u2019s disease, which remain without efficient treatment, display autoimmune and inflammatory components. We, therefore, hypothesized that As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    may be active on IBDs. Using the 2,4,6-trinitrobenzene sulfonic acid-induced murine model of colitis, we demonstrate that As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    used either in a preventive or a curative mode markedly reduced the induced colitis as assessed by macroscopic and microscopic scores, leading to prolonged mice survival. In addition, As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    was able to inhibit NF-\u03baB expression and DNA-binding in colon extracts leading to decreased cytokine gene expression (i.e. tumor necrosis factor-\u03b1, interleukin(IL)-1\u03b2, IL-12, IL-17, IL-18, and IL-23). Interestingly, As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    also reduced keratinocyte-derived chemokine (KC), inducible nitric oxide synthase (iNOS) mRNA levels, and myeloperoxidase (MPO) protein expression suggesting an impairment of neutrophils. This was associated with a marked increase of procaspase-3 and induced caspase-3 activation. This caspase-3 co-localized with MPO in the remaining neutrophils suggesting that As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    might have eliminated inflamed cells probably by inducing their apoptosis. These results assessed the potent anti-inflammatory effect of As\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    , that targets both NF-\u03baB and caspase-3 pathways, and suggests a therapeutic potential for Crohn\u2019s disease and other severe IBDs.\n                  <\/jats:p>","DOI":"10.1177\/1753425910371668","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T20:27:56Z","timestamp":1281126476000},"page":"365-374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-\u03baB down-regulation and caspase-3 activation"],"prefix":"10.1177","volume":"17","author":[{"given":"Monique","family":"Singer","sequence":"first","affiliation":[{"name":"INSERM U538, UPMC, UMRS 538, Faculty of Medicine Pierre et Marie Curie, Saint Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germain","family":"Trugnan","sequence":"additional","affiliation":[{"name":"INSERM U538, UPMC, UMRS 538, Faculty of Medicine Pierre et Marie Curie, Saint Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira K","family":"Chelbi-Alix","sequence":"additional","affiliation":[{"name":"CNRS FRE 2937, Villejuif, France,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,8,6]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2007.00310.x"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804812105"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2001.00905.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn246"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204762"},{"key":"atypb7","first-page":"3893","volume":"62","author":"Miller Jr WH","year":"2002","journal-title":"Cancer Res"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.5.1198"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(89)80079-4"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/S0022-3565(24)29641-5","volume":"297","author":"Nakase H.","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.3.267"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11991"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.4197"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.2046"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1038\/nm0996-998"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.487"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90760-9"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-146"},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0022-3565(24)29615-4","volume":"297","author":"Yue G.","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0408231"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.2.423.423"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.26.1.4618"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9949-4"},{"key":"atypb24","first-page":"15","author":"Scheiffele F.","year":"2002","journal-title":"Curr Protoc Immunol"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.05.001"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05866.x"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0708421"},{"issue":"15","key":"atypb28","first-page":"36","volume":"38","author":"Hibi T.","year":"2003","journal-title":"J Gastroenterol"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011268302386"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.148650"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.05.017"}],"container-title":["Innate Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425910371668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753425910371668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:59:31Z","timestamp":1777460371000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753425910371668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,6]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1177\/1753425910371668"],"URL":"https:\/\/doi.org\/10.1177\/1753425910371668","relation":{},"ISSN":["1753-4259","1753-4267"],"issn-type":[{"value":"1753-4259","type":"print"},{"value":"1753-4267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,6]]}}}