{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:19:36Z","timestamp":1779002376055,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T00:00:00Z","timestamp":1280793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>\n                    The regulation of interleukin (IL)-1 expression and secretion by salivary glands and macrophages in response to lipopolysaccharides (LPS) was compared. In wild-type mice, injection of LPS significantly decreased the volume of saliva stimulated by pilocarpine and increased its protein and amylase concentration. It did not modify the salivary concentration of IL-1\u03b2. The cytokine was expressed by submandibular acini and ducts. Macrophages also expressed IL-1\u03b2 but at lower concentration than salivary glands. The pre-incubation of macrophages with LPS increased the phosphorylation of I\u03baB and the expression of IL-1\u03b2. Adenosine triphosphate also promoted the secretion of the cytokine by these cells. These responses were absent in submandibular gland cells. These glands expressed CD14, TLR4 and MyD88. P2X\n                    <jats:sub>7<\/jats:sub>\n                    -KO mice secreted a lower volume of saliva which contained less proteins and amylase. In conclusion, IL-1\u03b2 is constitutively expressed by submandibular glands and its secretion is not regulated by a P2X\n                    <jats:sub>7<\/jats:sub>\n                    agonist. In these cells, LPS do not activate the nuclear factor-\u03baB\u2013pro-IL-1\u03b2 axis in spite of the expression of the proteins involved in their recognition.\n                  <\/jats:p>","DOI":"10.1177\/1753425910377101","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T20:55:10Z","timestamp":1280868910000},"page":"14-24","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Distinct regulation by lipopolysaccharides of the expression of interleukin-1\u03b2 by murine macrophages and salivary glands"],"prefix":"10.1177","volume":"18","author":[{"given":"M","family":"Seil","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie biologique et m\u00e9dicale et de Microbiologie pharmaceutique, Institut de Pharmacie, Universit\u00e9 libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M 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