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In this context, the potential of polyphenolic phytochemicals in preventing endotoxin-induced liver damage remains unclear. Here, we demonstrate that catechin and quercetin have the potential to down-regulate the initial signalling molecule NF-\u03baB which may further inhibit the downstream cascade including TNF-\u03b1 and NO. These results were confirmed using N-nitro-L-arginine methyl ester (L-NAME), the inhibitor of inducible nitric oxide synthase (iNOS) along with the biochemical and histological alterations occurring in the presence and absence of supplementation with both the polyphenols. However, catechin was found to be more effective than quercetin against endotoxin-induced liver injury. These findings suggest that these polyphenols may form a pharmacological basis for designing a therapeutic agent against endotoxin-mediated oxidative damage.<\/jats:p>","DOI":"10.1177\/1753425910393369","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T20:49:24Z","timestamp":1295038164000},"page":"70-79","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Down-regulation of NF-\u03baB signalling by polyphenolic compounds prevents endotoxin-induced liver injury in a rat model"],"prefix":"10.1177","volume":"18","author":[{"given":"Sushma","family":"Bharrhan","sequence":"first","affiliation":[{"name":"Department of Microbiology, Basic Medical Sciences Block, Panjab University, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanwaljit","family":"Chopra","sequence":"additional","affiliation":[{"name":"University Institute of Pharmaceutical 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