{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:04:14Z","timestamp":1792717454159,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T00:00:00Z","timestamp":1311897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Innate Immun"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>We have recently established a new experimental murine model for lipopolysaccharide (LPS)-mediated lethal shock with lung-specific injury. Severe lung injury is induced by administration of LPS into \u03b1-galactosylceramide (\u03b1-GalCer)-sensitized mice; the mice died with acute lung injury and respiratory distress within 24 h. \u03b1-GalCer activates natural killer T (NKT) cells in the lungs and liver, and induces the production of interferon (IFN)-\u03b3. However, IFN-\u03b3 signaling is only triggered in the lungs and makes them susceptible to LPS. On the other hand, IFN-\u03b3 signaling is inhibited in liver and results in few hepatic lesions. Unlike liver NKT cells, lung NKT cells fail to produce interleukin (IL)-4, which down-regulates the IFN-\u03b3 signaling, in response to \u03b1-GalCer. The differential cytokine profile between lung and liver NKT cells may lead to organ-specific lung lesions. The experimental system using \u03b1-GalCer sensitization could be a useful experimental model for clinical endotoxic or septic shock as it presents respiratory failure, a typical manifestation in severe septic patients. In this review, key evidence and the introducuction of the detailed mechanism of LPS-mediated lung-specific injury in \u03b1-GalCer-sensitized mice is provided. In particular, the molecular background of organ-specific development of lung injury in the model is focused on.<\/jats:p>","DOI":"10.1177\/1753425911410236","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T21:00:15Z","timestamp":1311973215000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["A new experimental murine model for lipopolysaccharide-mediated lethal shock with lung injury"],"prefix":"10.1177","volume":"18","author":[{"given":"Takashi","family":"Yokochi","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, 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